Role of Cord Blood Hormones and Epinephrine in the Development of Transient Tachypnea of the Newborn
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 70
- 主要终点
- Stress response at birth, as demonstrated by cord cortisol, adrenocorticotropic hormone, epinephrine, fT3, fT4, and thyroid-stimulating hormone in late preterm and term neonates developing transient tachypnea of the newborn.
研究概览
简要总结
In this prospective, cross-sectional study, the aim was to investigate the possible role of cord stress hormones; adrenocorticotropic hormone (ACTH), cortisol, epinephrine, sT3, sT4, and thyroid-stimulating hormone (TSH) in the development of Transient Tachypnea of the Newborn (TTN), via their modulatory effect on epithelial sodium channels and Na-K-ATPase.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 34 Weeks 至 40 Weeks（Child）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Gestation age > 34 weeks
- •C/S delivered infants
- •Parental consent form signed
排除标准
- •Gestation age < 34 weeks
- •Maternal conditions that compromised fetal well-being (hypertensive disorder, diabetes, chorioamnionitis)
- •Intrauterine growth retardation
- •Congenital malformations
- •Absence of parental consent
结局指标
主要结局
Stress response at birth, as demonstrated by cord cortisol, adrenocorticotropic hormone, epinephrine, fT3, fT4, and thyroid-stimulating hormone in late preterm and term neonates developing transient tachypnea of the newborn.
时间窗: postnatal first 24 hours
At birth cord blood samples and perinatal data were collected from ceseraen deliveries of late preterm and term infants. Cord stress hormones of the infants with the diagnosis of TTN and gestational age matched controls were analyzed.
次要结局
未报告次要终点