ACTRN12612000203853Completed未知
Effects of protein load on antropyloroduodenal motility, gut hormone release, and sensations of appetite in obese males.
Dr Natalie Luscombe-Marsh0 sites32 target enrollmentStarted: February 17, 2012Last updated:
Conditions
Trial Snapshot
- Phase
- 未知
- Status
- Completed
- Sponsor
- Enrollment
- 32
Study Overview
Brief Summary
No summary available.
Study Design
- Study Type
- Interventional
- Allocation
- Randomised controlled trial
- Primary Purpose
- Treatment
- Masking
- Blinded (masking used)
Eligibility Criteria
- Ages
- 18 Years to 60 Years (—)
- Sex
- Male
Inclusion Criteria
- •Obese with a Body Mass Index (BMI) of 30-35 kg/m2 and lean with a BMI of 18-25 kg/m2.
- •Weight stable (<5% fluctuation in body weight in previous 3 months).
Exclusion Criteria
- •Significant gastrointestinal symptoms, disease, or surgery
- •Use of prescribed or non-prescribed medications (including vitamins and herbal supplements) which may effect energy metabolism, gastrointestinal function, body weight, or appetite (eg. domperidone and cisapride, anticholinergic drugs (eg. atropine), metoclopramide, erythromycin, hyoscine, orlistat, green tea extracts, astragalus, St. johns wort etc.)
- •Lactose intolerant or other food allergies; intolerance or allergy to paracetomol
- •Current gallbladder or pancreatic disease; diabetes mellitus; epilepsy; cardiovasculr or respiratory diseases; any other illnesses as assessed by the investigator (including chronic illnesses not explicitly listed above)
- •Individuals with low ferritin levels or who have donated blood in the 12 weeks prior to taking part in the study
- •High performance athletes
- •Current intake of >2 standard drinks on >5 days per week
- •Current smokers of cigarettes/cigars/marijuana
- •Current intake of any illicit substance
- •Restrained eaters (score >12 on the three factor eating questionnaire)
- •Experience claustrophobia in confined spaces
- •Unable to tolerate nasogastrointestinal tube, or to comprehend study protocol
Investigators
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