Effects of intraduodenal protein, on energy intake, appetite, antropyloroduodenal motility, amino acids, hormones and glucose in undernourished compared with healthy older individuals

Dr Stijn Soenen0 个研究点目标入组 24 人开始时间: 2012年8月27日最近更新: 2020年1月13日

适应症

试验速览

暂无简介。

•Undernourished older people:
•at risk of malnourishment + malnourishment defined by a well validated, widely used, screening tool that is associated with poor outcomes in older people: the Mini Nutritional Assessment (MNA) with a score <24 out of 30
•and, at least one of: self-reported weight loss in the previous 3 months, or a Body Mass Index (BMI) <22 kg/m2
•'Healthy' older people:
•BMI: 20-30 kg/m2
•Weight stable (<5% fluctuation in body weight in previous 3 months).

•Significant gastrointestinal symptoms, disease, or surgery.
•Current gallbladder or pancreatic disease; diabetes mellitus; epilepsy; cardiovasculr or respiratory diseases; any other illnesses as assessed by the investigator (including chronic illnesses not explicitly listed above).
•Impaired cognitive function.
•Depression.
•Use of prescribed or non-prescribed medications (including vitamins and herbal supplements) which may effect gastrointestinal function or appetite.
•Lactose intolerant or other food allergies; intolerance or allergy to paracetomol.
•Individuals with low ferritin levels or who have donated blood in the 12 weeks prior to taking part in the study.
•Current intake of >2 standard drinks on >5 days per week.
•Current smokers of cigarettes/cigars/marijuana.
•Current intake of any illicit substance.
•Experience claustrophobia in confined spaces.
•Unable to tolerate nasogastrointestinal tube, or to comprehend study protocol.

发起方

Dr Stijn Soenen