Effects of protein load on gut motility, gut hormone release, and sensations of appetite.
- Conditions
- ObesityDiet and Nutrition - ObesityOral and Gastrointestinal - Normal oral and gastrointestinal development and function
- Registration Number
- ACTRN12612000203853
- Lead Sponsor
- Dr Natalie Luscombe-Marsh
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Male
- Target Recruitment
- 32
Obese with a Body Mass Index (BMI) of 30-35 kg/m2 and lean with a BMI of 18-25 kg/m2.
Weight stable (<5% fluctuation in body weight in previous 3 months).
Significant gastrointestinal symptoms, disease, or surgery
Use of prescribed or non-prescribed medications (including vitamins and herbal supplements) which may effect energy metabolism, gastrointestinal function, body weight, or appetite (eg. domperidone and cisapride, anticholinergic drugs (eg. atropine), metoclopramide, erythromycin, hyoscine, orlistat, green tea extracts, astragalus, St. johns wort etc.)
Lactose intolerant or other food allergies; intolerance or allergy to paracetomol
Current gallbladder or pancreatic disease; diabetes mellitus; epilepsy; cardiovasculr or respiratory diseases; any other illnesses as assessed by the investigator (including chronic illnesses not explicitly listed above)
Individuals with low ferritin levels or who have donated blood in the 12 weeks prior to taking part in the study
High performance athletes
Current intake of >2 standard drinks on >5 days per week
Current smokers of cigarettes/cigars/marijuana
Current intake of any illicit substance
Restrained eaters (score >12 on the three factor eating questionnaire)
Experience claustrophobia in confined spaces
Unable to tolerate nasogastrointestinal tube, or to comprehend study protocol
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method