Exploratory randomized trial of evaluation for Tiotropium in lung cancer surgery
- Conditions
- Primary lung cancer
- Registration Number
- JPRN-UMIN000012217
- Lead Sponsor
- Yokohama City University Medical Center
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up continuing
- Sex
- All
- Target Recruitment
- 43
Not provided
1) Median sternotomy. 2) Combined resection of the chest wall excluding parietal pleura excision. 3) History of active infection. 4) Active double cancer within 5 years of disease-free interval, except for curable lesions like carcinoma in situ and mucosal cancer. 5) Patients with glaucoma. 6) Patients with dysuria. 7) History of hypersensitivity to atropine or drugs similar to atropine. 8) Patients with interstitial pneumonia or pulmonary fibrosis. 9) Patients with arrhythmia requiring antiarrhythmic continuously. 10) Patients with thyropathy. 11) Patients with renal dysfunction needs blood purification therapy. 12) Patients with psychiatric disease. 13) Patients requiring systemic steroids medication. 14) Patients with uncontrolled diabetes mellitus. 15) Patients with uncontrolled hypertension. 16) Current or previous within the last 6 months history of severe heart diseases, cerebrovascular disease. 17) The pregnant and lactating female , female who has possibility of the pregnancy. 18) Patients who were judged inappropriate to entry this study by physician.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Rate of cardiopulmonary complications within 1 year after surgery
- Secondary Outcome Measures
Name Time Method 1)Improvement of pulmonary function before and after inhalation of Tiotropium 2)Rate of post operative complications excluding cardiopulmonary complications 3)3-years overall survival 4)Rate of adverse events 5)Evaluation of postoperative compliance