Pleural Fluid Neutrophil Extracellular Traps Exacerbate Disease Severity and Risk of One-year Mortality in Pleural Infection (TORPIDS-3)

Active, not recruiting

• Conditions: Pleural Infection

• Registration Number: NCT07194915
• Lead Sponsor: University of Oxford

Brief Summary

Pleural infection is a severe and complicated disease which is associated with significant morbidity and mortality. People with pleural infection show diverse levels of neutrophil degranulation activity. The investigators examined the biological role of pleural fluid neutrophil extracellular traps in patients with pleural infection. TORPIDS-3 is an observational, International multicohort study.

Detailed Description

Not available

Study Timeline

• Study Start: 2024-01-09
• Primary Completion: 2025-08-31
• Status Verified: 2025-09
• Study First Submitted: 2025-09-10
• Study First Submitted QC: 2025-09-18
• Last Update Submitted: 2025-09-18
• Study First Posted: 2025-09-26
• Last Update Posted: 2025-09-26
• Study Completion: 2025-10-01

Recruitment & Eligibility

• Status: ACTIVE_NOT_RECRUITING
• Sex: All
• Target Recruitment: 326

Inclusion Criteria

Patients were included if they had a clinical presentation consistent with pleural infection as stated in the Methods section of the main manuscript and any of the following criteria:

1. Pleural fluid that was macroscopically purulent, OR
2. Pleural fluid that was positive on culture for bacterial infection, OR
3. Pleural fluid that demonstrated bacteria on Gram staining, OR
4. Pleural fluid with pH ≤7.2 (measured in a blood gas analyser) or low glucose level (≤3mmol/L or ≤55mg/dL) in a patient with clinical evidence of infection, OR
5. Contrast-enhanced CT evidence of pleural infection (consolidation of underlying lung with enhancing pleural collection) in a patient with clinical evidence of infection, alongside exclusion of other sources of infection.

Exclusion criteria:

1. Age less than 18 years, OR
2. No pleural fluid available for analysis, OR
3. Patient previous pneumonectomy on the side of pleural infection, OR
4. Expected survival less than three months due to co-morbid disease, as judged by the recruiting physician

Exclusion Criteria

Not provided

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Disease severity	Baseline	Association between pleural fluid NETs with disease severity
One-year mortality	Baseline	Association between pleural fluid NETs and risk of one-year mortality

Secondary Outcome Measures

Name	Time	Method
Need for Intrapleural Enzyme Therapy (IET)	Baseline	Association between pleural fluid NETs with the requirement for IET
Bacterial profiles	Baseline	Association between pleural fluid NETs with bacterial profiles
Sonographic septations	Baseline	Association between pleural fluid NETs and the presence of sonographic septations

Trial Locations

Locations (1)

CAMS Oxford Institute, Nuffield Department of Medicine; 🇬🇧 Oxford, United Kingdom