Effects of Allopurinol on Diastolic Function in Chronic Heart Failure Patients
Phase 4
Completed
- Conditions
- Chronic Heart Failure
- Registration Number
- NCT00477789
- Lead Sponsor
- Universita di Verona
- Brief Summary
In patients with chronic heart failure (CHF)due to dilated cardiomyopathy diastolic dysfunction occurs frequently and is related to a poor outcome. We have previously shown that parameters of diastolic function significantly correlate with uric acid levels, a marker of impaired oxidative metabolism. We aimed to determine whether inhibition of xanthine oxidase with allopurinol might affect diastolic function in patients with CHF.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- Not specified
Inclusion Criteria
- chronic heart failure;
- left ventricular systolic dysfunction (ejection fraction <45%)
- stable clinical conditions in the previous three months
- optimal medical therapy for CHF
- normal sinus rhythm
- written informed consent
- age >18 years
Exclusion Criteria
- renal failure (s-creatinine >2.5 mg/dl)
- already on allopurinol
- malignancies
- chronic inflammatory diseases
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method diastolic function uric acid levels BNP three months
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Division of Cardiology, University Hospital of Verona
🇮🇹Verona, Italy