NCT00477789已完成4 期
Effects of Allopurinol on Diastolic Function in Chronic Heart Failure Patients
Universita di Verona1 个研究点 分布在 1 个国家开始时间: 2007年5月24日最近更新:
适应症
相关药物
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 发起方
- 试验地点
- 1
- 主要终点
- diastolic function uric acid levels BNP
研究概览
简要总结
In patients with chronic heart failure (CHF)due to dilated cardiomyopathy diastolic dysfunction occurs frequently and is related to a poor outcome. We have previously shown that parameters of diastolic function significantly correlate with uric acid levels, a marker of impaired oxidative metabolism. We aimed to determine whether inhibition of xanthine oxidase with allopurinol might affect diastolic function in patients with CHF.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •chronic heart failure;
- •left ventricular systolic dysfunction (ejection fraction <45%)
- •stable clinical conditions in the previous three months
- •optimal medical therapy for CHF
- •normal sinus rhythm
- •written informed consent
- •age >18 years
排除标准
- •renal failure (s-creatinine >2.5 mg/dl)
- •already on allopurinol
- •malignancies
- •chronic inflammatory diseases
结局指标
主要结局
diastolic function uric acid levels BNP
时间窗: three months
次要结局
未报告次要终点
研究者
研究点 (1)
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