A Randomized Controlled Trial to study the efficacy of administration of Atosiban before Embryo Transfer on In vitro Fertilisation
试验速览
- 阶段
- 4 期
- 状态
- 尚未招募
- 发起方
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Clinical pregnancy rate
研究概览
简要总结
Embryo implantation is the most crucial stage in assisted reproduction treatment. Uterine contractions triggered by the embryo transfer process might negatively impact embryo implantation. The impact of Atosiban on embryo implantation is related to the inverse correlation between the frequency of uterine contractions and the implantation rate.
Aims and Objectives: To study the effect of Atosiban administration before embryo transfer on In vitro Fertilisation.
Material and methods: A total of 100 women undergoing FET at Akanksha IVF centre fulfilling the inclusion and exclusion criteria will be included in the Randomized Controlled Trial.
Atosiban I.V. bolus of 6.75mg will be administered at approximately 30 minutes before Embryo transfer. Pregnancy outcome will be assessed in terms of implantation rate, biochemical pregnancy, clinical pregnancy and first trimestere miscarriage.
研究设计
- 研究类型
- Interventional
- 分配方式
- Other
- 盲法
- None
入排标准
- 年龄范围
- 23.00 Year(s) 至 40.00 Year(s)（—）
- 性别
- Female
入选标准
- •1 BMI less than 30kg per m2 2 Diagnosed with primary or secondary infertility 3 Normal uterus on 2D ultrasonography 4 Endometrial thickness greater than 7mm on the day of starting progesterone 5 Good quality embryo (Grade A Cleavage stage embryo or blastocyst).
排除标准
- 未提供
结局指标
主要结局
Clinical pregnancy rate
时间窗: 2 months | 4 months
Clinical pregnancy rate= Number of clinical pregnancies/Number of Embryo transfer cycles*100
时间窗: 2 months | 4 months
次要结局
- 1 Implantation rate(2 Biochemical pregnancy)
研究者
Dr K D Nayar
Akanksha IVF Centre New Delhi