The effect of N-acetylcystein in outcome and adverse effects of intubation in neonates
Not Applicable
- Conditions
- Respiratoty Distress Syndrome of neonates.Respiratory distress syndrome of newborn
- Registration Number
- IRCT138810012420N2
- Lead Sponsor
- Vice chancellor for research, Iran University of Medical Sciences and Health Services
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 65
Inclusion Criteria
Inclusion Criteria: Neovates > 1200 gram hospitalized in NICU of Rasoul Akram hospital and needed to be intubated and mechanically ventilated based on standard protocols.
Exclusion Criteria
Neonates with major anomalies or cyanotic cardiac diseases, neonates who ere intubated at the beginning of their hospitalization, neonates with pneumothorax at the time of hospitalization or intubation, massive hemorrhage, neonates who were extubated before 24 hours or dead before this time
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The duration of first intubation until exchange of endotracheal tube due to mucus plug retention. Timepoint: every 6 hours. Method of measurement: Tube cleaning with drugs in order to make sure that it's open.
- Secondary Outcome Measures
Name Time Method umber of endotracheal tube obstruction and replacement due to mucus plug. Timepoint: every 6 hours. Method of measurement: cleaning of the endotracheak tube to make sure that it's open.;Duration of intubation. Timepoint: every day. Method of measurement: observation.;Events those may be related to the new drug including apnoea and bradycardia, hypotension, pulmonary haemorrhage. Timepoint: every 6 hours. Method of measurement: monitoring of the patient.;Death. Timepoint: every 6 hours. Method of measurement: control of vital signs.