Multilevel Interventions to Increase Adherence to Lung Cancer Screening

Not Applicable

• Conditions: Lung Cancer; Lung Cancer Screening

• Registration Number: NCT05747443
• Lead Sponsor: Kaiser Permanente

Brief Summary

Screening for lung cancer has the potential for a profound public health benefit. Repeat annual screening is necessary for early detection of lung cancer. The investigators will test two interventions which include patient education and reminders to improve adherence to lung cancer screening.

Detailed Description

Screening for lung cancer has the potential for a profound public health benefit.

Successful population-based screening requires continuous monitoring to adherence repeat screening in high risk adults to achieve similar results. Repeat annual screening is necessary for early detection of lung cancer. Baseline or first LDCT scans detect prevalent lung cancer, when subsequent screening detects new nodules. However, adherence to screening is low, ranging at 28-38% from centers nationally.

The investigators developed two novel, patient-centered interventions to address patient education and offering reminders for on-time screening. To address these goals, the specific aims are to: 1) Compare effectiveness of two multilevel interventions relative to usual care in improving (a) rates of adherence to lung cancer screening, (b) patient-centered outcomes; and (c) clinic outcomes; and 2) Determine the patient-, clinician-, and system-level factors that influence changes in adherence to inform lung cancer screening programs.

Study Timeline

• Study Start: 2022-12-12
• Study First Submitted: 2023-02-17
• Study First Submitted QC: 2023-02-17
• Study First Posted: 2023-02-28
• Status Verified: 2023-03
• Last Update Submitted: 2023-03-06
• Last Update Posted: 2023-03-08
• Primary Completion: 2025-06-01
• Study Completion: 2026-06-30

Recruitment & Eligibility

• Status: ENROLLING_BY_INVITATION
• Sex: All
• Target Recruitment: 1606

Inclusion Criteria

• KPWA members
• Aged 50-78 years
• Have a negative screening LDCT scan
• Speak English or Spanish
• Meet US Preventive Services Task Force guidelines

Exclusion Criteria

• Patients who were previously diagnosed with lung cancer,
• Patients who have a positive scan,
• Patients who have an indicator for interpreter services, except for Spanish

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: FACTORIAL

Primary Outcome Measures

Name	Time	Method
Rate of repeat annual lung cancer screening	9-15 months after index LDCT	Electronic health records will be searched for screening low dose CT (LDCT).

Secondary Outcome Measures

Name	Time	Method
Knowledge of lung cancer screening	8 weeks after index LDCT	Knowledge of lung cancer screening eligibility, time to return and cost on patient reported outcomes survey.
Attitudes and beliefs	8 weeks after index LDCT	The Lung Cancer Screening Health Belief Scale measures self-efficacy for lung cancer screening. The self-efficacy for lung cancer screening scale ranges from 9-36, with higher scores indicating lower self-efficacy.

Trial Locations

Locations (1)

Kaiser Permanente; 🇺🇸 Seattle, Washington, United States