Spirometry in Mechanically Ventilated Chronic Obstructive Pulmonary Disease (COPD) Patients

• Conditions: COPD

• Registration Number: NCT00965029
• Lead Sponsor: Assaf-Harofeh Medical Center

Brief Summary

Patients with COPD who deteriorate to Respiratory Failure pose a challenge to the intensivist both in ventilating an obstructed patient and in weaning from mechanical ventilation.

Currently there are no accepted extubation criteria in COPD patients that could predict successful weaning from mechanical ventilation. In this study we will attempt to correlate spirometric data to eventual weaning from mechanical ventilation.

Detailed Description

COPD patients who deteriorate to Respiratory Failure will be recruited. Sedation will be interrupted daily, and each day once the patient is awake and cooperative, spirometry will be performed. FEV1 and FVC will be recorded and later correlated to eventual rate of successful extubation.

Study Timeline

• Status Verified: 2009-08
• Study First Submitted: 2009-08-24
• Study First Submitted QC: 2009-08-24
• Study First Posted: 2009-08-25
• Study Start: 2009-09
• Last Update Submitted: 2011-04-04
• Last Update Posted: 2011-04-05
• Primary Completion: 2012-09
• Study Completion: 2012-09

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• >18
• Mechanically ventilated due to COPD exacerbation

Exclusion Criteria

• decreased level of consciousness
• uncooperative patient
• Bronchial asthma

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Trial Locations

Locations (1)

Arie Soroksky; 🇮🇱 Beer Yaakov, Zerifin, Israel