Clinical study of Qurs-e-Mafasil Jadeed with and without Hijama in knee joints pai
- Conditions
- Health Condition 1: M179- Osteoarthritis of knee, unspecified
- Registration Number
- CTRI/2019/04/018450
- Lead Sponsor
- Central Council for Research in Unani Medicine
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Open to Recruitment
- Sex
- Not specified
- Target Recruitment
- 0
Patients of any sex aged 40-70 years
Patients having Moderate to severe Knee pain (pain more than 40 mm and less than 90 mm) after 50 feet Walking on a flat surface
Patients of Knee OA with chronicity of more or equal to 6 months
Patients having K L Grading criteria of grades II or III
Patients with normal laboratory values.
Patients willing to comply with the regular treatment schedule as per protocol
Anemia (less than 10g percent of Hb) and bleeding disorders
Pregnant and Lactating Mothers
Another type of arthritis, eg Rheumatoid arthritis, Psoriatic arthritis, Gouty arthritis
Patients taking Anticoagulants, corticosteroid or NSAIDs or any other concomitant therapy
History of Surgery, Tidal lavage/Arthroscopy of the joint involved, of affected knee within the past 1 year. Intra-articular (IA) corticosteroid injection of affected knee within a 3 months interval prior to baseline screening
Patients with the gastro-intestinal disease, peptic ulcer and having fecal blood loss
History of Systemic illness such as Liver, Kidney, Cardiac disorders, DM, HTN, Osteomyelitis, Tuberculosis,
Known cases of Immunocompromised states (HIV or AIDS, etc.)/ Malignancies
Patients who were not willing to be randomized
Ongoing use of prohibited medication including NSAID, another oral analgesic, muscle relaxant, or a low-dose antidepressant for any chronic pain management
Concomitant skin disease at the application site
History of alcohol or Drug abuse, excessive smoking,
Diagnosed neurological or psychiatric disorders
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Tenderness on the joint area <br/ ><br>Effusion and Swelling over the affected joint <br/ ><br>Range of movements (Goniometry) <br/ ><br>Walking timeTimepoint: At baseline, 2wk, 4wk, 6wk and end of the 8wk
- Secondary Outcome Measures
Name Time Method X-ray grading <br/ ><br>Biomarkers used <br/ ><br>Assessment of safetyTimepoint: At baseline and end of the 8wk