The Clinical and Pathological Significance of Allelic Imbalance of 8p in Patients With Colorectal Cancer
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Colorectal Cancer
- Sponsor
- Alliance for Clinical Trials in Oncology
- Enrollment
- 598
- Locations
- 59
- Primary Endpoint
- overall survival
- Status
- Completed
- Last Updated
- 9 years ago
Overview
Brief Summary
RATIONALE: Genetic studies may help in understanding the genetic processes that cause some types of cancer.
PURPOSE: Genetic trial to study certain genes of patients who have stage II or stage III colon cancer.
Detailed Description
OBJECTIVES: * Determine the adverse prognostic significance of 8p allelic imbalance (AI) in patients with colon cancer. * Determine if patient prognosis is dependent on the region of 8p AI. * Perform fine mapping studies to further localize the putative tumor suppressor gene(s) on 8p. * Perform multicolor FISH to examine the role that 8p loss and 8q gain play in the prognosis of patients whose tumors exhibit 8p AI. OUTLINE: Matched normal and tumor DNA is analyzed for 8p allelic imbalance with at least 8 markers: D8S262 and D8S1825 localized to 8p23, D8S254 and D8S261 at 8p22, D8S560 and D8S136 at 8p21, and D8S1820 and D8S283 at 8p12. Normal/tumor tissue pairs are used for fine mapping studies.
Investigators
Eligibility Criteria
Inclusion Criteria
- Not provided
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
overall survival
Time Frame: Up to 10 years