Genetic Study in Patients With Stage II or Stage III Colon Cancer
- Conditions
- Colorectal Cancer
- Interventions
- Genetic: DNA stability analysisGenetic: gene mapping
- Registration Number
- NCT00003833
- Lead Sponsor
- Alliance for Clinical Trials in Oncology
- Brief Summary
RATIONALE: Genetic studies may help in understanding the genetic processes that cause some types of cancer.
PURPOSE: Genetic trial to study certain genes of patients who have stage II or stage III colon cancer.
- Detailed Description
OBJECTIVES:
* Determine the adverse prognostic significance of 8p allelic imbalance (AI) in patients with colon cancer.
* Determine if patient prognosis is dependent on the region of 8p AI.
* Perform fine mapping studies to further localize the putative tumor suppressor gene(s) on 8p.
* Perform multicolor FISH to examine the role that 8p loss and 8q gain play in the prognosis of patients whose tumors exhibit 8p AI.
OUTLINE: Matched normal and tumor DNA is analyzed for 8p allelic imbalance with at least 8 markers: D8S262 and D8S1825 localized to 8p23, D8S254 and D8S261 at 8p22, D8S560 and D8S136 at 8p21, and D8S1820 and D8S283 at 8p12. Normal/tumor tissue pairs are used for fine mapping studies.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 598
Not provided
Not provided
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Normal and tumor tissue pairs DNA stability analysis Matched normal and tumor DNA is analyzed for 8p allelic imbalance with at least 8 markers: D8S262 and D8S1825 localized to 8p23, D8S254 and D8S261 at 8p22, D8S560 and D8S136 at 8p21, and D8S1820 and D8S283 at 8p12. Normal/tumor tissue pairs are used for fine mapping studies. Normal and tumor tissue pairs gene mapping Matched normal and tumor DNA is analyzed for 8p allelic imbalance with at least 8 markers: D8S262 and D8S1825 localized to 8p23, D8S254 and D8S261 at 8p22, D8S560 and D8S136 at 8p21, and D8S1820 and D8S283 at 8p12. Normal/tumor tissue pairs are used for fine mapping studies.
- Primary Outcome Measures
Name Time Method overall survival Up to 10 years
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (59)
British Columbia Cancer Agency
🇨🇦Vancouver, British Columbia, Canada
Cape Breton Cancer Centre
🇨🇦Sydney, Nova Scotia, Canada
Tom Baker Cancer Center - Calgary
🇨🇦Calgary, Alberta, Canada
Lethbridge Cancer Clinic
🇨🇦Lethbridge, Alberta, Canada
Nanaimo Cancer Clinic
🇨🇦Nanaimo, British Columbia, Canada
British Columbia Cancer Agency - Fraser Valley Cancer Centre
🇨🇦Surrey, British Columbia, Canada
Prostate Centre at Vancouver General Hospital
🇨🇦Vancouver, British Columbia, Canada
St. Paul's Hospital - Vancouver
🇨🇦Vancouver, British Columbia, Canada
Nova Scotia Cancer Centre
🇨🇦Halifax, Nova Scotia, Canada
Newfoundland Cancer Treatment and Research Foundation
🇨🇦St. Johns, Newfoundland and Labrador, Canada
Hamilton and District Urology Association
🇨🇦Hamilton, Ontario, Canada
London Health Sciences Centre
🇨🇦London, Ontario, Canada
North York General Hospital, Ontario
🇨🇦North York, Ontario, Canada
Male Health Centre/CMX Research Inc.
🇨🇦Oakville, Ontario, Canada
Toronto East General Hospital
🇨🇦Toronto, Ontario, Canada
Cancer Care Ontario - Windsor Regional Cancer Centre
🇨🇦Windsor, Ontario, Canada
Humber River Regional Hospital
🇨🇦Weston, Ontario, Canada
L'Hopital Laval
🇨🇦Ste-Foy, Quebec, Canada
Queen Elizabeth Hospital, PEI
🇨🇦Charlottetown, Prince Edward Island, Canada
CHUS-Hopital Fleurimont
🇨🇦Fleurimont, Quebec, Canada
Hopital Charles Lemoyne
🇨🇦Greenfield Park, Quebec, Canada
Centre Hospitalier de l'Universite de Montreal
🇨🇦Montreal, Quebec, Canada
Maisonneuve-Rosemont Hospital
🇨🇦Montreal, Quebec, Canada
Centre Hospitalier Regional de Lanaudiere
🇨🇦Joliette, Quebec, Canada
McGill University
🇨🇦Montreal, Quebec, Canada
Hopital du Saint-Sacrament, Quebec
🇨🇦Quebec City, Quebec, Canada
Saskatoon Cancer Centre
🇨🇦Saskatoon, Saskatchewan, Canada
Hopital Sainte Justine
🇨🇦Montreal, Quebec, Canada
Kells Medical Research Group Inc.
🇨🇦Pointe Claire, Quebec, Canada
Lions Gate Hospital
🇨🇦North Vancouver, Canada
Hopital Du Sacre-Coeur de Montreal
🇨🇦Montreal, Quebec, Canada
Centre Hospitalier Universitaire de Quebec
🇨🇦Quebec City, Quebec, Canada
Centre Hospitalier Regional de Rimouski
🇨🇦Rimouski, Quebec, Canada
G. Steinhoff Clinical Research
🇨🇦Victoria, British Columbia, Canada
Doctor Leon Richard Oncology Centre
🇨🇦Moncton, New Brunswick, Canada
William Osler Health Centre
🇨🇦Brampton, Ontario, Canada
Markham Stouffville Hospital
🇨🇦Markham, Ontario, Canada
St. Mary's/Duluth Clinic Health System
🇺🇸Duluth, Minnesota, United States
Saint Joseph's Health Centre - Toronto
🇨🇦Toronto, Ontario, Canada
Allan Blair Cancer Centre
🇨🇦Regina, Saskatchewan, Canada
Moncton Hospital
🇨🇦Moncton, New Brunswick, Canada
Saint John Regional Hospital
🇨🇦Saint John, New Brunswick, Canada
Trillium Health Centre
🇨🇦Mississauga, Ontario, Canada
Credit Valley Hospital
🇨🇦Mississauga, Ontario, Canada
York County Hospital
🇨🇦Newmarket, Ontario, Canada
Lakeridge Health Oshawa
🇨🇦Oshawa, Ontario, Canada
Toronto Sunnybrook Regional Cancer Centre
🇨🇦Toronto, Ontario, Canada
Mount Sinai Hospital - Toronto
🇨🇦Toronto, Ontario, Canada
St. Michael's Hospital - Toronto
🇨🇦Toronto, Ontario, Canada
Princess Margaret Hospital
🇨🇦Toronto, Ontario, Canada
Toronto General Hospital
🇨🇦Toronto, Ontario, Canada
Women's College Campus, Sunnybrook and Women's College Health Science Center
🇨🇦Toronto, Ontario, Canada
Royal Victoria Hospital, Barrie
🇨🇦Barrie, Ontario, Canada
Peterborough Oncology Clinic
🇨🇦Peterborough, Ontario, Canada
Scarborough Hospital - General Site
🇨🇦Scarborough, Ontario, Canada
Hotel Dieu Health Sciences Hospital - Niagara
🇨🇦St. Catharines, Ontario, Canada
Northeastern Ontario Regional Cancer Centre, Sudbury
🇨🇦Sudbury, Ontario, Canada
Ottawa Regional Cancer Centre
🇨🇦Ottawa, Ontario, Canada
Northwestern Ontario Regional Cancer Centre, Thunder Bay
🇨🇦Thunder Bay, Ontario, Canada