Ketoacid Analogues Intradialytic Effect on Inflammation
- Conditions
- Hemodialysis Complication
- Interventions
- Drug: Ketoacid
- Registration Number
- NCT06392516
- Lead Sponsor
- RSUP Fatmawati
- Brief Summary
this study tries to measure the effect of intradialytic ketoacid analogues on inflammatory parameters
- Detailed Description
this study will measure inflammation parameters:
* interleukin 6
* malnutrition inflammation score
* neutrophil lymphocyte ratio
* monocyte lymphocyte ratio
* thrombocyte lymphocyte ratio
the duration of intervention is 12 weeks
Recruitment & Eligibility
- Status
- NOT_YET_RECRUITING
- Sex
- All
- Target Recruitment
- 86
- patient who undergo hemodialysis two times a week
- travelling hemodialysis
- acute conditions
- HIV patient
- acute infection
- stroke and immobilized patient
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description intervention Ketoacid will be given parenteral ketoacid analogues intradialytics two times a week
- Primary Outcome Measures
Name Time Method interleukin-6 12 weeks in pg/mL, no limit values
monocyte lymphocyte ratio 12 weeks the percentage ratio of monocyte count and lymphocyte count will be combined to monocyte lymphocyte ratio
malnutrition inflammation score 12 weeks consists of ten components, based on subjective complaints combined with albumin serum (in g/dL), serum iron (in micromol/L, and total iron binding capacity (in micromol/L). the sum of all components \>5 means have high inflammation status
neutrophil lymphocyte ratio 12 weeks the percentage ratio of neutrophil count and lymphocyte count will be combined to neutrophil lymphocyte ratio
thrombocyte lymphocyte ratio 12 weeks the percentage ratio of thrombocyte (in per microliter of blood) and lymphocyte count will be combined to thrombocyte lymphocyte ratio
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
RSUP Fatmawati
🇮🇩Jakarta, Jakarta Selatan, Indonesia