The Effects of Sex Hormones on Cognition and Mood in Older Adults

Not Applicable

Terminated

• Conditions: Mood Disorders; Cognition Disorders

• Registration Number: NCT00000175
• Lead Sponsor: National Institute on Aging (NIA)

Brief Summary

This study is investigating the effects of hormone replacement therapy on memory, mental abilities and mood in older adults aged 65-90. During the nine month long study, men will take testosterone for three months and women will take estrogen for three months. At four points during the study (once every three months), participants will complete a test battery and have blood drawn.

Detailed Description

Double-blind, placebo-controlled, crossover study investigating the effects of estrogen replacement and testosterone replacement on cognition and mood in older adults. Women who have not had a hysterectomy will be given Prempro (estrogen with progesterone to protect the uterine lining), and hysterectomized women will be given Premarin (estrogen only).

Study Timeline

• Study First Submitted: 1999-10-29
• Study First Submitted QC: 1999-10-29
• Study First Posted: 1999-11-01
• Status Verified: 2004-03
• Primary Completion: 2005-06
• Study Completion: 2005-06
• Last Update Submitted: 2009-12-10
• Last Update Posted: 2009-12-11

Recruitment & Eligibility

• Status: TERMINATED
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

• Women and men aged 65-90 who have not received hormone replacement for the last three months.

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Exclusion Criteria

• Previous head injury with loss of consciousness for more than one hour.
• Men with a history of prostate cancer.
• Men on testosterone replacement within the past three months.
• Women with a history of breast or uterine cancer.
• Women on estrogen replacement within the past three months.

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Trial Locations

Locations (1)

Gerontology Research Center; 🇺🇸 Baltimore, Maryland, United States