NL-OMON41443已完成不适用
Blood-brain barrier permeability in cerebral small vessel disease: a dynamic contrast-enhanced MRI study. - Blood-brain barrier in cerebral small vessel disease
Medisch Universitair Ziekenhuis Maastricht0 个研究点目标入组 120 人开始时间: 待定最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 120
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18 至 99（—）
入选标准
- •LACI patients: A first-ever acute lacunar stroke ;Mild VCI due to cSVD:
- •- Subjective complaints of cognitive functioning and objective cognitive impairment in at least 1 cognitive domain on cognitive testing, and
- •- A Clinical Dementia Rating <=1 and a MMSE >=20 (i.e. no dementia), and
- •- Vascular lesions on brain MRI (lacunar infarts, white matter lesions, deep microbleeds) that suggest a link between the cognitive deficit and cSVD.;Healthy control subjects: Healthy control subjects are included from the general population and matched to the LACI and mild VCI patients according to gender and age.
排除标准
- •Exclusion criteria for all subjects:
- •Cerebrovascular abnormalities in history
- •o Ischemic stroke
- •o Haemorrhagic stroke (subarachnoid or intracerebral)
- •Contra indications for MRI/DCE-MRI
- •o Heart valve prosthesis
- •o Pacemaker
- •o Intracerebral clips (aneurysm)
- •o Intra-ocular metal pieces
- •o Cochlear implant
- •o Claustrophobia
- •o Poor kidney function (GFR<30ml/min)
- •o Previous allergic reaction to contrast agent (gadobutrol)
- •Psychiatric disorders associated with (temporarily) cognitive decline (e.g. depression, psychosis);Group specific exclusion criteria:
- •Lacunar stroke
- •- Potential cardiac embolic source (e.g. atrial fibrillation)
- •- Stenosis of >=50% of one or both internal carotid arteries.
- •Mild cognitive impairment due to cSVD
- •- Clinical and/or subclinical cortical events
- •- Other causes for cognitive impairment (e.g. Alzheimers Disease)
- •Healthy subjects
- •- Clinically overt cardiovascular diseases
- •- Clinically overt cerebrovascular diseases
- •- Disease of the central nervous system (e.g. Multiple Sclerosis, brain tumor/metastasis)
- •- Extensive structural lesions on MRI associated with cSVD
- •- Cognitive impairment (i.e. objective and/or subjective cognitive deficits).
研究者
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