Epidemiology of Weaning From Invasive Mechanical Ventilation in COVID-19. Observational and Multicenter Study.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 326
- 试验地点
- 2
- 主要终点
- weaning rate
研究概览
简要总结
This report is a multicenter, observational, analytical and prospective study. The objective was to describe the weaning of mechanical ventilation in patients with SARS-CoV-2 and the clinical results according to the different types of weaning.
详细描述
This report is a multicenter, observational, analytical and prospective study.
Patients older than 18 years with a diagnosis of COVID-19 by PCR + and who required invasive VM for more than 12 hours from April 1 to August 30, 2020 were included. Subjects admitted to pediatric ICUs and in the recovery room were excluded. Patients who were readmitted and required a new cycle of MV after having been successfully weaned and released from the hospital were also excluded. All patients with data loss greater than 10% in variables considered clinically relevant were eliminated.
The weaning process from mechanical ventilation in each patient was classified by two strategies:
Definition of critical care medicine consensus conference published (2007) in:
Simple weaning: Patients successfully extubated after the first weaning attempt.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Diagnosis of COVID-19 by PCR +
- •Invasive mechanical ventilation for more than 12 hours
排除标准
- •Subjects admitted to pediatric ICUs and surgery recovery room.
- •Patients who were readmitted and required a new cycle of invasive mechanical ventilation after having been successfully weaned and released from the hospital.
结局指标
主要结局
weaning rate
时间窗: on day 28
percentage of successfully weaned patients
weaning classification
时间窗: on day 28
number of spontaneous breathing tests and days from first spontaneous breathing test to success or death
次要结局
- mechanical ventilation days(on day 28)
- length of ICU stay(on day 28)
研究者
Matias Accoce
HEAD OF RESPIRATORY THERAPY
Sanatorio Anchorena San Martin