Clinical evaluation of dietary intake of carrot juice in preventing ultraviolet-induced (UV) erythema formatio

Not Applicable

• Conditions: Healthy adults

• Registration Number: JPRN-UMIN000035471
• Lead Sponsor: Kagome CO., LTD.

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2019-01-08
• Study Completion: 2019-05-31
• Last Update Posted: 17 October 2023

Recruitment & Eligibility

• Status: Complete: follow-up complete
• Sex: Male
• Target Recruitment: 68

Inclusion Criteria

Not provided

Exclusion Criteria

1) Subjects who are hospitalized for their disease treatment or who takes medicine 2) Subjects who habitually takes medicine such as anti-histamine drugs, anti-inflammatory drugs, and sedatives 3) Subjects who have risk of skin allergies and subjects with a diagnosis of photo sensitive disorder 4) Subjects who are hospitalized in dermatology department 5) Subjects who have risk of pollen allergies and using medicine during the study period 6) Subjects who have risk of allergies to carrot juice 7) Subjects who dislike carrot juice or vegetable juice 8) Subjects who have blister after sunburn 9) Subjects whose upper arms are extremely skinny 10) Subjects with apparent pigmentation, inflammation, and other diseases in the test area 11) Subjects who cannot avoid to be exposed to exceeded UV-light than in daily life by activities including long hours of outwork, sports, and leisure activities 12) Subjects who have a plan to go abroad, sea bathing, etc. during the study period 13) Subjects who take special care of facial skin 14) Subjects who are feeding vegetable-based diet 15) Subjects who habitually consume carrot juice, vegetable juice, or beta-carotene-rich foods 16) Subjects who habitually consume carotenoid-rich supplements 17) Subjects who habitually use pharmaceuticals, quasi-drugs, and supplements effective in the treatment of UV-induced skin pigmentation and chloasma, such as L-cysteine-containing drugs, vitamin-C-containing drugs, and tranexamic acid-containing drugs 18) Subjects who habitually use pharmaceuticals, quasi-drugs, supplements, and health claim foods effective in skin moisture retention 19) Subjects with smoking habit 20) Subjects who habitually consume higher amount of alcohol 21) Subjects who have participated in other human studies within the past 2 months, or who are participating 22) Subjects who had artificial UV-treatment within the past 2 months

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Skin color (a* and erythema index) on the UV -irradiated region and minimum erythema dose (MED) at 0, 8, and 12 weeks after intake of test foods

Secondary Outcome Measures

Name	Time	Method
Skin color (L*), Melanin index, Stratum corneum hydration, Transepidermal water loss, Index of skin regeneration