Analysis of Genomic Alterations in Sporadic Cases of Multiple Myeloma
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 1,000
- 试验地点
- 1
- 主要终点
- DNA mutations associated with the existence of multiple myeloma
研究概览
简要总结
There is a growing body of data suggesting that the the risk of developing multiple myeloma, or myelomagenesis, is associated with genetic alterations occurring in the tumor cells. A limited number of candidate genes and polymorphisms have been reported in patients with this disease. In this study the investigators will compare the genetic information obtained on purified abnormal plasmocytes obtained from patients with multiple myeloma with available public databases in an effort to identify and if possible validate the role of certain mutations and/or polymorphisms in myelomagenesis. Plasmocytes will be obtained by immunomagnetic enrichment using CD138+ beads.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •diagnosis of multiple myeloma
- •availability of abnormal plasmocytes
排除标准
- 未提供
结局指标
主要结局
DNA mutations associated with the existence of multiple myeloma
时间窗: through study completion, an average of 1 year
DNA data acquired in myeloma patient samples will be compared to those of healthy subjects using publically available databases.
次要结局
未报告次要终点