Hyaluronic Acid Gel in Ridge Preservation

Phase 4

Completed

• Conditions: Hyaluronic Acid Gel for Preservation the Extraction Socket
• Interventions: Other: empty socket; Drug: Hyaluronic acid

• Registration Number: NCT06176937
• Lead Sponsor: Ain Shams University

Brief Summary

hyaluronic acid gel applied at the extraction socket after extraction immediately to preserve the socket from post extraction resorption. hyaluronic acid has ability for osteogenesis and new bone formation.

Detailed Description

twenty-four patients with one hopeless tooth at least, first CBCt before extraction to evaluate the dimension of the socket, then atraumatic extraction of the tooth to preserve the bony wall of the socket, after extraction and curettage the socket applied hyaluronic acid gel inside the socket and applied collagen membrane to secure the socket. After 4 months of extraction, CBCt was done to evaluate the dimension of the socket and the effect of hyaluronic acid. Furthermore, The core biopsy was taken by trephine bur at the time of implant placement for evaluate the histological appearance of the bone to evaluate the secondary outcome. then after three months the crown was delivered as a prosthetic part.

Study Timeline

• Status Verified: 2020-01
• Study Start: 2021-10-13
• Primary Completion: 2022-02-26
• Study Completion: 2022-08-20
• Study First Submitted: 2023-09-13
• Study First Submitted QC: 2023-12-17
• Last Update Submitted: 2023-12-17
• Study First Posted: 2023-12-20
• Last Update Posted: 2023-12-20

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 24

Inclusion Criteria

1. Healthy adult patients as evidenced by Burkett's oral medicine health history questionnaire

2. Both genders.

3. Age from 20 -50 years old.

4. Having at least one hopeless teeth indicated for extraction.

5. Esthetic zone teeth (anterior or premolar).

6. Sockets type 1 or 2 .

7. Patient should agree to sign a written consent after the nature of the study will be explained.

Exclusion Criteria

1- Smokers. 2- Pregnant and breast-feeding females. 3- Mentally retarded Patients. 4- Prisoners and handicapped patients. 5- Patients with malocclusion.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
empty socket	empty socket	extraction socket without application any drug
hyaluronic acid gel	Hyaluronic acid	Hyaluronic acid considers as a high molecular weight glycosaminoglycan (GAG) consists of multiple disaccharide non-sulfated units of D-glucuronic acid and N-acetylglucosamine

Primary Outcome Measures

Name	Time	Method
Radiographic measurement	baseline (before extraction)/ four months later after extraction	Radiographic measurement of bone height by CBCt before and 4 months after extraction.
clinical outcome	baseline(before extraction)/ four months later after extraction	measurement clinical bone width of the socket by millimeter before and 4 months after extraction ...

Secondary Outcome Measures

Name	Time	Method
histomorphometric analysis	after 4 months of extraction at the time of implant placement.	The bone biopsy will be taken by trephine bur. And evaluate bone quantity.
histological analysis	after 4 months of extraction at the time of implant placement.	The bone biopsy will be taken by trephine bur. And evaluate bone quality.

Trial Locations

Locations (1)

Ain shams University; 🇪🇬 Cairo, Egypt