Efficacy of Hyaluronic Acid Gel in Ridge Preservation After Tooth Extraction: A Randomized Controlled Clinical Trial With Radiographic and Histomorphometric Study
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 24
- 试验地点
- 1
- 主要终点
- Radiographic measurement
研究概览
简要总结
hyaluronic acid gel applied at the extraction socket after extraction immediately to preserve the socket from post extraction resorption. hyaluronic acid has ability for osteogenesis and new bone formation.
详细描述
twenty-four patients with one hopeless tooth at least, first CBCt before extraction to evaluate the dimension of the socket, then atraumatic extraction of the tooth to preserve the bony wall of the socket, after extraction and curettage the socket applied hyaluronic acid gel inside the socket and applied collagen membrane to secure the socket. After 4 months of extraction, CBCt was done to evaluate the dimension of the socket and the effect of hyaluronic acid. Furthermore, The core biopsy was taken by trephine bur at the time of implant placement for evaluate the histological appearance of the bone to evaluate the secondary outcome. then after three months the crown was delivered as a prosthetic part.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 20 Years 至 50 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Healthy adult patients as evidenced by Burkett's oral medicine health history questionnaire
- •Both genders.
- •Age from 20 -50 years old.
- •Having at least one hopeless teeth indicated for extraction.
- •Esthetic zone teeth (anterior or premolar).
- •Sockets type 1 or 2 .
- •Patient should agree to sign a written consent after the nature of the study will be explained.
排除标准
- •1- Smokers. 2- Pregnant and breast-feeding females. 3- Mentally retarded Patients. 4- Prisoners and handicapped patients. 5- Patients with malocclusion.
研究组 & 干预措施
hyaluronic acid gel
Hyaluronic acid considers as a high molecular weight glycosaminoglycan (GAG) consists of multiple disaccharide non-sulfated units of D-glucuronic acid and N-acetylglucosamine
干预措施: Hyaluronic acid (Drug)
empty socket
extraction socket without application any drug
干预措施: empty socket (Other)
结局指标
主要结局
Radiographic measurement
时间窗: baseline (before extraction)/ four months later after extraction
Radiographic measurement of bone height by CBCt before and 4 months after extraction.
clinical outcome
时间窗: baseline(before extraction)/ four months later after extraction
measurement clinical bone width of the socket by millimeter before and 4 months after extraction ...
次要结局
- histomorphometric analysis(after 4 months of extraction at the time of implant placement.)
- histological analysis(after 4 months of extraction at the time of implant placement.)