Pistachio and blood glucose response
- Conditions
- Adults with pre diabetes
- Registration Number
- CTRI/2020/11/029340
- Lead Sponsor
- American Pistachio Growers
- Brief Summary
Indiandiets are high in GL mainly derived from the 3 meals, a positive study outcome wouldhelp to provide evidence that as little as 30g of roasted pistachio in eachday’s breakfast and dinner over 12 weeks could help to reduce GL in Indiandiets. Indian diets are also deficient in MUFA with the current intake of 6.9%E(median) providing only half of the recommended intake. Addition of 60g ofpistachio providing 11.4g of MUFA could increase the MUFA calories to 11%E. Thiswill support the hypothesis that replacing carbohydrates with pistachio (with goodquality of fat especially MUFA) would not only reduce the metabolic risk but alsoimprove the overall quality of the Asian Indian diet as pistachios are a richsource of protein, MUFA and other phytonutrients that are currently low in Indiandiets. In addition, intake of 60g roasted pistachio per day will help toimprove the daily intake of PUFA particularly n3-PUFA, alpha linolenic acid (ALNA)intake by about 15-17%.
This studywill give an insight on the efficacy of roasted pistachios on modulating cardiometabolicrisk and especially glucose and insulin related parameters. This will then be asimple dietary tool for physicians, dietitians and other health careprofessionals to promote and enable improved dietary adherence and a betterstrategy to reduce the risk of diabetes by reducing the metabolic risk factorsfor diabetes.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Not Yet Recruiting
- Sex
- All
- Target Recruitment
- 120
Hypertension Pre-diabetes (Impaired fasting glucose: fasting capillary blood glucose ≥110mg/dl and <126mg/dl and/or Impaired glucose tolerance: plasma glucose 2-hrs post after 75g glucose load ≥140mg/dl but <200mg/dl).
- Self-reported diabetes Current daily and weekly tobacco users History of allergy to nuts Patients on oral steroids, metformin, on hormonal replacement therapy History of bariatric surgery or have underwent any major surgery in last 6 months Use of nutritional supplements Bad dentures Patients with cancer, Patients on medications for psychiatric disorders, Active weight loss (more than 3 kg in the last month) •Pregnant/lactating women Presence of severe liver, kidney, thyroid, or other endocrine diseases Any condition that hinders compliance to the intervention.
- Possible eating disorder.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Changes in 1) fasting glucose, 2) 2hour post glucose load; 2 time points | 1.Baseline-at the time of study commencement | 2.End- at the end of 3 months
- Secondary Outcome Measures
Name Time Method Changes in Insulin resistance measured by HOMA-IR
Trial Locations
- Locations (1)
MADRAS DIABETES RESEARCH FOUNDATION
🇮🇳Chennai, TAMIL NADU, India
MADRAS DIABETES RESEARCH FOUNDATION🇮🇳Chennai, TAMIL NADU, IndiaMrs Sudha VasudevanPrincipal investigator9840014480s2r_7@mdrf.in