Dyspnoea in Pulmonary Arterial Hypertension: Targeting the Diaphragm muscle

Completed

Conditions: aandoeningen van de ademhalingsspieren
Pulmonary arterial hypertension diaphragm dysfunction
10028302
10037454

Registration Number: NL-OMON36056

Lead Sponsor: Academisch Medisch Centrum

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 26

Inclusion Criteria

- Patients with chronic thromboembolic pulmonary hypertension scheduled for a pulmonary thrombo endarterectomy.
- Age: > 18 years
- Gender: Both male and female
- all ethnic backgrounds

Exclusion Criteria

- COPD (GOLD stage II-IV) and CHF (NYHA class III-IV)
- Neuromuscular disease
- chronic use of corticosteroids (defined as >7.5 mg/day for at least 3 months)
- >10% weight loss within last 6 months

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Main study parameter/endpoint: Contractile force and structure of single<br /><br>diaphragm muscle fibers</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secondary study parameters/endpoints: * Morphological determination of muscle<br /><br>fiber cross sectional area * Muscle fiber ultrastructure by electronmicrocopy <br /><br>Posttranslational modification of contractile proteins Diaphragm cytokine<br /><br>profile * Gene expression analysis by Affymetrix<br /><br>* Comparison of findings from diaphragm muscle to those from the<br /><br>non-respiratory pectoralils major muscle * Correlation between diaphragm muscle<br /><br>fiber strength and pulmonary function</p><br>