Autoregulation of Glomerular Filtration Rate in Patients With Type 1 Diabetes During Spironolactone Therapy
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 17
- 主要终点
- Changes in glomerular filtration rate
研究概览
简要总结
To evaluate the impact of spironolactone treatment on renal autoregulation in hypertensive type 1 diabetic patients.
详细描述
Double-masked, randomized, crossover trial. In random order, patients will be treated with spironolactone 25 mg o.d. and matched placebo for 28 days.
On the last day of treatment, GFR will be determined twice on the same day: first without clonidine and secondly after injection of clonidine (clonidine induces a transient reduction in blood pressure, with no influence on renal plasma flow and GFR), in order to evaluate the effect of antihypertensive treatment with spironolactone on renal autoregulation of GFR.
The study will be preceded by a wash-out period of 1 month for patients receiving antihypertensive medication. Patients will be instructed to measure blood pressure twice daily, three days a week during this period. If, during the washout period, blood pressure exceeds 170/105 mm Hg or persistent edemas develop, treatment with long-acting loop diuretics will be initiated and continued throughout the rest of the study. If blood pressure despite diuretic treatment still exceeds 170 mm Hg systolic and/or 105 mm Hg diastolic, the patient will be excluded from the study and previous/appropriate antihypertensive treatment will be restarted.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- Double
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Type 1 diabetes
- •Age between 18 and 70 years
- •Blood pressure ≥ 135 mm Hg systolic and/or ≥ 85 mm Hg diastolic or ongoing antihypertensive treatment
- •Informed consent
排除标准
- •Diabetic nephropathy
- •Other known kidney or renal tract disease
- •Malignant hypertension
- •Blood pressure > 170/105 at baseline or during AHT wash-out period
- •Plasma potassium > 4.7 mmol/l
- •Elevated plasma creatinine (>88 µmol/l for women and >100 µmol/l for men)
- •Symptoms of Ischemic heart disease within 3 months prior to study start
- •Previous cerebrovascular event (apoplexy, TCI)
- •Abuse of medicine or alcohol
- •Pregnancy or breastfeeding
- •Woman of child-bearing age who are not using adequate contraception
- •ASA treatment > 1g/day or regular use of NSAIDs
- •Known allergy to or side-effects of spironolactone
- •Inability to understand patient information
结局指标
主要结局
Changes in glomerular filtration rate
次要结局
- Changes in blood pressure
- Changes in albuminuria
- Changes in fractional albumin clearance