Pilot Study: a Comparative Study Between Serum Levels of Oxytocin and Incitement to Use Olfactory Stimuli in Restrictive Anorexia Nervosa in Adolescents
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- Score "Wanting" to olfactory stimuli
研究概览
简要总结
This prospective pilot study will compare adolescents with restrictive anorexia nervosa who participated for 3 months at olfactory workshops, patients who did not, and healthy patients.The groups will be evaluated before the workshops and after three months, with the wanting score after olfactory stimuli and with serum oxytocin level.
详细描述
The restrictive anorexia nervosa (AN) in adolescents is an eating disorder with decreased desire to eat (wanting) following olfactory stimulation. Oxytocin is an hormone involved in the neuromodulation of eating behavior, but also involved in olfactory perception in schizophrenia patients, and in social cognition in patients with autism. Its plasma level was found low in anorexic patients compared to control subjects.
Because of the similarity in disorders of social cognition between these three diseases, we assume that the desire to eat evoked by olfactory perception varies with the plasma oxytocin levels.
With a prospective pilot study we will compare patients with AN who participated for 3 months at olfactory workshops, AN patients who did not, and healthy patients.
The groups will be evaluated before the workshops and after three months, with the wanting score after olfactory stimuli and with serum oxytocin level.
One application of this study will be the use of ocytocyne nasal spray to increase the eating desire and to allow weight regain
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Health Services Research
- 盲法
- None
入排标准
- 年龄范围
- 11 Years 至 18 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Medical-Review
- •Female or male -Sexe,
- •11 to 18 years
- •Anorexia nervosa diagnosed according to the criteria DSM V
- •Outpatient care or hospitalization
- •Be able to answer the clinicals evaluations questionnaires
- •Affiliated to social security
- •Consentement of the legal representative and the patient
排除标准
- •Somatic comorbidity associated with diabetes, celiac disease, brain tumor
- •Intolerance odors, predisposed to develop asthma and / or respiratory allergies Pathologie chronic rhino-sinus
- •Hyposmiques or anosmic
- •Patients not of an inclusion criteria
研究组 & 干预措施
olfactory workshop
Influence of sensory therapy on the rate of oxytocin
干预措施: olfactory workshop (Other)
other workshop
Influence of other workshop on the rate of oxytocin
干预措施: other workshop (Other)
control group
Rate of oxytocin of the control group
干预措施: No intervention (Other)
结局指标
主要结局
Score "Wanting" to olfactory stimuli
时间窗: at 3 months
次要结局
- Body mass index(at 3 months)
- Oxytocin serum level(at 3 months)
- Scores to clinical scales(at 3 months)
- Scores to "liking"-"wanting" tests(at 3 months)
- Scores to hedonicity scale(at 3 months)