Evaluation of PLB Physiology in COPD - Untersuchung Zur Physiologie Der Lippenbremse Bei COPD
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- COPD
- Sponsor
- Karl Josef Franke, PD DR med
- Enrollment
- 110
- Locations
- 1
- Primary Endpoint
- Lung function parameter FEV1
- Status
- Completed
- Last Updated
- 4 years ago
Overview
Brief Summary
Simulation of pursed-lips breathing by defined stenoses in pulmonary function diagnostics to quantify the effect of the pursed-lips breathing
Detailed Description
Since many years it is recommended for COPD patients to reduce the crossdiameter of the lips in order to improve the exhalation by means of so-called pursed-lips breathing (PLB). But the effects have never been studied quantitatively. In this study, the PLB effect is simulated during lung function diagnostics, using different sized resistors inserted into the routine mouthpiece of the flow sensor to resemble the effective airway resistances of a PLB maneuver. This prospective, randomized study includes 20 healthy subjects and 50 COPD patients, who will perform lung function testing with 4 different sized resistors.
Investigators
Karl Josef Franke, PD DR med
Clinical Director
Institut für Pneumologie Hagen Ambrock eV
Eligibility Criteria
Inclusion Criteria
- •COPD (GOLD I- IV)
- •Stable respiratory situation that allows routine lung funtion
- •capable of communication
- •Lung Healthy
- •capable of communication
Exclusion Criteria
- •Invasive Ventilation
- •Other serious acute physical illnesses that require immediate intensive medical treatment
- •Acute hypercapnic decompensation with a pH \< 7.35 in the capillary BGA
- •Pregnancy or Nursing
- •Not able to give consent
- •Not willing or able to follow the study protocol
Outcomes
Primary Outcomes
Lung function parameter FEV1
Time Frame: up to 1 hour
Measuring of lung function parameters with different resistors to simulate PLB unit: L, measured with der MasterScreen™ Body, CareFusion
Secondary Outcomes
- RV%TLC(up to 1 hour)
- PEF - expiratory Peak Flow(up to 1 hour)