Individual Differences After Consumption of Alcohol and Other Common Substances and Long-Term Follow-Up of Social Drinking, Young Adults
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 入组人数
- 800
- 试验地点
- 2
- 主要终点
- Subjective response to alcohol and other common substances utilizing mood questionnaires in adult drinkers
研究概览
简要总结
This study attempts to elucidate the factors that contribute to escalation and maintenance of excessive ethanol drinking in young adults by:
- Examining subjective and objective response differences to alcohol and other common substances in a sample of adults with varying consumption patterns.
- Determining whether response to alcohol and other substances is predictive of future consumption patterns through longitudinal follow-up interviews.
- Examining the relationship between responses to alcohol and other substances at baseline and re-examination testing to evaluate if consumption patterns moderate this relationship.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Screening
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 21 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age 21-65
- •Weigh between 110-210 lbs
- •Drink alcohol at least once weekly with weekly "binge" drinking episodes
- •Available to complete in-person screening and 2, 4 hour experimental sessions at the University of Chicago
- •Available by phone, mail, or Internet for follow-up interviews for at least 2 years following sessions
排除标准
- •Current or past major medical or psychiatric disorders including alcohol and substance dependence
研究组 & 干预措施
Beverage in Natural Environment
Participant consumes alcohol containing beverages or non-alcohol beverages in natural environment
Beverage with No alcohol (Placebo)
Beverage containing 0.0 g/kg alcohol to act as placebo
干预措施: Placebo (Drug)
Beverage with Low Alcohol Dose
Beverage containing 0.4 g/kg alcohol
干预措施: Ethanol (Drug)
Beverage with Heavy Alcohol Dose
Beverage containing 0.8 g/kg alcohol
干预措施: Ethanol (Drug)
Beverage with Caffeine
Beverage containing the equivalent of 1.5 times participant's average caffeine consumption
干预措施: Caffeine (Drug)
Beverage with Diphenhydramine
Beverage containing 1.5 standard dose of Diphenhydramine (Benadryl)
干预措施: Diphenhydramine (Drug)
结局指标
主要结局
Subjective response to alcohol and other common substances utilizing mood questionnaires in adult drinkers
时间窗: Measured during 5 timepoints at each experimental session: 1) Pre-drink baseline, 2) +30 minutes, 3) +60 minutes, 4) +120 minutes, and 5) +180 minutes following the initiation of beverage consumption
次要结局
- Substance Use Behavior Reported During Follow-Up Interviews(Measured at 3, 6, 9, 12, 15, 18, 21, 24, 36, 48, and 60 months following the final experimental session)