Situation and Evolution of the Misuse of Alcohol and Other Addictive Behaviors in Obese Patients Being Managed at Nîmes University Hospital
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 800
- 试验地点
- 1
- 主要终点
- Presence of alcohol abuse evaluated at the first clinical consultation according to the DSM-5 questionnaire
研究概览
简要总结
Obesity is a multifactorial pathology in which external (lifestyle, environment) and internal (psychological or biological, especially genetic) factors are involved. These are responsible for a positive energy balance. One of the external factors that can intervene in the genesis of obesity is the existence of eating disorders: bulimic hyperphagia. Some teams consider bulimic hyperphagia as a form of addiction. After bariatric surgery, the appearance of new addictions has been observed.
In connection with Pr Perney's addictology department, the investigators have observed that some patients under treatment for obesity at the endocrinology department subsequently developed other addictions, in particular misuse of alcohol.
The hypotheses of this research are :
There appears to be a transfer from eating disorders to substance misuse addiction in post-treatment of obesity, particularly in patients who have undergone bariatric surgery.
The misuse of addictive substances most concerned by this transfer of addiction in the post-treatment of obesity, particularly after bariatric surgery, seems to be the misuse of alcohol.
This will be the first French cohort study on addictive behaviors in patients undergoing bariatric surgery and the first international study including non-operated obese patients benefiting from medical care alone. This study will improve the multidisciplinary management of these patients by integrating addictologists.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patient being managed for the first time at Nîmes University Hospital Obesity Clinic ( complete hospitalization, outpatients' or consultation).
- •Patient being managed for obesity defined by a body mass index (BMI) of 30 kg.m-² or over
- •Patient affiliated to or covered by a health insurance scheme.
- •Adult patient (≥ 18 years).
排除标准
- •Patient with psychiatric disorder reducing capacity for comprehension.
- •Patient in an exclusion period determined by another study.
- •Patient under legal guardianship, tutorship or curatorship.
- •Patient to whom it is impossible to give clear information
- •Patient who is pregnant, about to give birth or breastfeeding.
结局指标
主要结局
Presence of alcohol abuse evaluated at the first clinical consultation according to the DSM-5 questionnaire
时间窗: Month 24
The DSM-5 criteria are used to identify depression in all patients with high alcohol consumption (over14 glasses a week for women, 21 for men, or more than 4 glasses on one occasion). The DSM-5 outlines the following criterion to make a diagnosis of depression. The individual must be experiencing five or more symptoms during the same 2-week period and at least one of the symptoms should be either (1) depressed mood or (2) loss of interest or pleasure.
Presence of alcohol abuse evaluated at the first clinical consultation according to the AUDIT(Alcohol Use Disorders Identification Test) questionnaire.
时间窗: Month 24
The Alcohol Use Disorders Identification Test (AUDIT) self-questionnaire consists of 10 questions covering consumption (the first 3 questions), behaviors that may evoke dependency (not being able to stop drinking, inability to carry out one's plans, needing a drink in the morning) and problems related to alcohol consumption (guilt or remorse, memory loss, injuries, concerns from family and friends). Each question can be scored from 0 (low) - 4 (high) points, leading to a possible total score of 40 points.This questionnaire therefore makes it possible to cover all aspects of alcohol misuse in a very short space of time. It has been validated with good diagnostic performance: sensitivity at 92% and specificity at 94% for a threshold ≥ 8 (Saunders et al. 1993; Coulton et al. 2006). Moreover, this questionnaire is very widely used and recognized in scientific articles on addictology.
Presence of alcohol abuse evaluated at the first clinical consultation according to the AUDIT(Alcohol Use Disorders Identification Test) questionnaire.
时间窗: Day 0
The Alcohol Use Disorders Identification Test (AUDIT) self-questionnaire consists of 10 questions covering consumption (the first 3 questions), behaviors that may evoke dependency (not being able to stop drinking, inability to carry out one's plans, needing a drink in the morning) and problems related to alcohol consumption (guilt or remorse, memory loss, injuries, concerns from family and friends). Each question can be scored from 0 (low) - 4 (high) points, leading to a possible total score of 40 points. This questionnaire therefore makes it possible to cover all aspects of alcohol misuse in a very short space of time. It has been validated with good diagnostic performance: sensitivity at 92% and specificity at 94% for a threshold ≥ 8 (Saunders et al. 1993; Coulton et al. 2006). Moreover, this questionnaire is very widely used and recognized in scientific articles on addictology.
Presence of alcohol abuse evaluated at the first clinical consultation according to the AUDIT(Alcohol Use Disorders Identification Test) questionnaire.
时间窗: Month 12
The Alcohol Use Disorders Identification Test (AUDIT) self-questionnaire consists of 10 questions covering consumption (the first 3 questions), behaviors that may evoke dependency (not being able to stop drinking, inability to carry out one's plans, needing a drink in the morning) and problems related to alcohol consumption (guilt or remorse, memory loss, injuries, concerns from family and friends).Each question can be scored from 0 (low) - 4 (high) points, leading to a possible total score of 40 points. This questionnaire therefore makes it possible to cover all aspects of alcohol misuse in a very short space of time. It has been validated with good diagnostic performance: sensitivity at 92% and specificity at 94% for a threshold ≥ 8 (Saunders et al. 1993; Coulton et al. 2006). Moreover, this questionnaire is very widely used and recognized in scientific articles on addictology.
Presence of alcohol abuse evaluated at the first clinical consultation according to the DSM-5 questionnaire
时间窗: Day 0
The DSM-5 criteria are used to identify depression in all patients with high alcohol consumption (over14 glasses a week for women, 21 for men, or more than 4 glasses on one occasion). The DSM-5 outlines the following criterion to make a diagnosis of depression. The individual must be experiencing five or more symptoms during the same 2-week period and at least one of the symptoms should be either (1) depressed mood or (2) loss of interest or pleasure.
Presence of alcohol abuse evaluated at the first clinical consultation according to the DSM-5 questionnaire
时间窗: Month 12
The DSM-5 criteria are used to identify depression in all patients with high alcohol consumption (over14 glasses a week for women, 21 for men, or more than 4 glasses on one occasion). The DSM-5 outlines the following criterion to make a diagnosis of depression. The individual must be experiencing five or more symptoms during the same 2-week period and at least one of the symptoms should be either (1) depressed mood or (2) loss of interest or pleasure.
次要结局
- Use of hallucinogenic drugs and/or new synthetic drugs(Month 24)
- Cannabis addiction(Month 24)
- Quality of Life according to the EQVOD scale(Month 24)
- Use of cocaine(Month 24)
- Smoking (tobacco addiction) according to the Fagerström test(Month 24)
- Use of amphetamines(Month 24)
- Use of opioids(Month 24)
- Eating disorders(Month 24)
- Comorbidities(Month 24)
- Anxiety and Depression(Month 24)
- Binge eating(Month 24)
- Cannabis addiction(Month 12)
- Use of cocaine(Day 0)
- Smoking (tobacco addiction) according to the Fagerström test(Day 0)
- Smoking (tobacco addiction) according to the Fagerström test(Month 12)
- Cannabis addiction(Day 0)
- Use of cocaine(Month 12)
- Use of amphetamines(Day 0)
- Use of amphetamines(Month 12)
- Use of opioids(Day 0)
- Use of opioids(Month 12)
- Use of hallucinogenic drugs and/or new synthetic drugs(Day 0)
- Use of hallucinogenic drugs and/or new synthetic drugs(Month 12)
- Eating disorders(Day 0)
- Eating disorders(Month 12)
- Comorbidities(Day 0)
- Comorbidities(Month 12)
- Quality of Life according to the EQVOD scale(Day 0)
- Quality of Life according to the EQVOD scale(Month 12)
- Anxiety and Depression(Day 0)
- Anxiety and Depression(Month 12)
- Binge eating(Day 0)
- Binge eating(Month 12)