The Acute Effects of a Single Bout of Exercise on Asthmatic Airway Inflammation: A Pilot Study
- Conditions
- AsthmaRespiratory - Asthma
- Registration Number
- ACTRN12613001014741
- Lead Sponsor
- Hunter Medical Research Institute
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 20
Doctor diagnosed asthma; stable asthma (no respiratory tract infection, oral corticosteroid use or antibiotic use in the 4 weeks preceding the intervention visits); 18-65 years of age and body mass index (BMI) <=40kg/m2; never or ex-smokers (last cigarette at least 6 months prior); FEV1 >50% predicted. GP clearance for exercise must be provided for females aged >50 years, males aged >40 years, and all participants who respond ‘yes’ to any question in Part A of the Adult Pre-Exercise Screening Tool”.
Current smoker; cardiac contraindication to exercise; cancer; pregnancy or breastfeeding; currently undertaking exercise training (>=90 minutes per week); any issue that in the opinion of the investigator would impede the participants safety and/or ability to undertake the exercise intervention; participation in an exercise session within 3 days of the scheduled study visit.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Exhaled nitric oxide (eNO), which will be measured using an Ecomedics nitric oxide analyser.[0, 1, 2, 4 and 24 hours (versus baseline)]
- Secondary Outcome Measures
Name Time Method Plasma eosinophil count[0, 1, 2 and 24 hours (versus baseline)];Plasma Interleukin (IL)-5[0, 1, 2 and 24 hours (versus baseline)];Plasma IL-4[0, 1, 2 and 24 hours (versus baseline)];Plasma IL-10[0, 1, 2 and 24 hours (versus baseline)];C-reactive protein (CRP)[0, 1, 2 and 24 hours (versus baseline)]