The Effects of Caffeinated Coffee on Intraocular Pressure
- Conditions
- Primary Open Angle Glaucoma
- Interventions
- Other: Caffeinated CoffeeOther: Decaffeinated Coffee
- Registration Number
- NCT01364207
- Lead Sponsor
- Massachusetts Eye and Ear Infirmary
- Brief Summary
High intraocular pressure (IOP) is a known risk factor for developing primary open-angle glaucoma (POAG). There is controversy in the literature regarding the degree to which caffeine influences IOP, with some studies reporting minimal changes in IOP while others report up to 4 mmHg increases. To date there are no double-masked randomized controlled trials that examine acute caffeinated coffee's effects on IOP in patients with or at risk for primary open-angle glaucoma. The investigators aim to better understand the relationship between acute caffeinated coffee (vs decaffeinate coffee) consumption and IOP in a double-masked, crossover randomized controlled clinical trial.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 112
- 40-89 yrs
- POAG for cases or no forms of glaucoma for controls
- Willingness to drink coffee
- Consent signed
- Age less than 40 or greater than 89 yrs
- all forms of glaucoma other than POAG
- any condition inappropriate for tonometry (ie corneal disease, LASIK)
- unable or unwilling to give consent
- unable or unwilling to drink coffee
- pregnancy
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Arm && Interventions
Group Intervention Description Caffeinated Coffee 1st Visit, Decaffeinated Coffee 2nd Visit Caffeinated Coffee Participants will be given an 8 oz cup of caffeinated coffee on their first visit and 8 oz cup of decaffeinated coffee on their second visit. Caffeinated Coffee 1st Visit, Decaffeinated Coffee 2nd Visit Decaffeinated Coffee Participants will be given an 8 oz cup of caffeinated coffee on their first visit and 8 oz cup of decaffeinated coffee on their second visit. Decaffeinated Coffee 1st Visit, Caffeinated Coffee 2nd Visit Caffeinated Coffee Participants will be given an 8 oz cup of decaffeinated coffee on their first visit and 8 oz cup of caffeinated coffee on their second visit. Decaffeinated Coffee 1st Visit, Caffeinated Coffee 2nd Visit Decaffeinated Coffee Participants will be given an 8 oz cup of decaffeinated coffee on their first visit and 8 oz cup of caffeinated coffee on their second visit.
- Primary Outcome Measures
Name Time Method Change in Intraocular Pressure at 60 Minutes Prior to coffee ingestion (baseline), 60 minutes post coffee ingestion At the caffeinated coffee visit: Change in intraocular pressure at 60 minutes = intraocular pressure at 60 minutes post caffeinated coffee ingestion minus intraocular pressure at baseline prior to caffeinated coffee ingestion
At the decaffeinated coffee visit: Change in intraocular pressure at 60 minutes = intraocular pressure at 60 minutes post decaffeinated coffee ingestion minus intraocular pressure at baseline prior to decaffeinated coffee ingestionChange in Intraocular Pressure at 90 Minutes Prior to coffee ingestion (baseline), 90 minutes post coffee ingestion At the caffeinated coffee visit: Change in intraocular pressure at 90 minutes = intraocular pressure at 90 minutes post caffeinated coffee ingestion minus intraocular pressure at baseline prior to caffeinated coffee ingestion
At the decaffeinated coffee visit: Change in intraocular pressure at 90 minutes = intraocular pressure at 90 minutes post decaffeinated coffee ingestion minus intraocular pressure at baseline prior to decaffeinated coffee ingestion
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Massachusetts Eye and Ear Infirmary
🇺🇸Boston, Massachusetts, United States