Microvascular Function in Non-ST-segment Elevation Acute Coronary Syndrome

Completed

Conditions: microvascular dysfunction
NSTEMI
10011082
10003216

Registration Number: NL-OMON42844

Lead Sponsor: Academisch Medisch Centrum

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 60

Inclusion Criteria

1. Stable angina (CCS class I to III, or Braunwald class I) or NSTE-ACS (Chest pain within the preceding 5 days and an index event >24 hours from time of angiography but within the previous 7 days).;2. Scheduled for percutaneous coronary intervention or intracoronary evaluation of functional stenosis severity (diagnostic catheterization).;3. The presence of at least one normal or minimally diseased reference coronary artery (<30% diameter stenosis on visual assessment) with a vessel diameter of more than 2.5 mm.

Exclusion Criteria

1. Younger than 19 or older than 80 years of age.;2. Recent ST-segment elevation myocardial infarction (<6 weeks prior to enrollment).;3. Inability to receive intravenous adenosine (for example, severe reactive airway disease, marked hypotension, or high-grade AV block without pacemaker).;4. Known renal insufficiency (eGRF according to MDRD <30 mL/min/m2).;5. Known severe valvular abnormalities.;6. Known severe left ventricular dysfunction (LV ejection fraction <30%) or known myocardial hypertrophy (septal wall thickness at echocardiography of >13 mm).;7. Extremely tortuous or calcified coronary arteries precluding intracoronary physiologic measurements.;8. Women of child bearing age not on active birth control;9. Inability to sign an informed consent, due to any mental condition that renders the subject unable to understand the nature, scope, and possible consequences of the trial or due to mental retardation or language barrier.

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>To document the magnitude of microvascular resistance in patients with NSTE-ACS<br /><br>versus patients with stable coronary artery disease, as obtained from Doppler<br /><br>flow velocity-derived and thermodilution mean transit time-derived surrogates<br /><br>of coronary flow.</p><br>

Secondary Outcome Measures