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Clinical Trials/NCT05416203
NCT05416203
Completed
Not Applicable

Brief Enhanced Anxiety Sensitivity Treatment: A Pilot Study

VA Office of Research and Development1 site in 1 country15 target enrollmentSeptember 1, 2022

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Anxiety Sensitivity
Sponsor
VA Office of Research and Development
Enrollment
15
Locations
1
Primary Endpoint
Mean Change in Anxiety Sensitivity
Status
Completed
Last Updated
10 months ago

Overview

Brief Summary

This pilot study trial will test the acceptability, feasibility, and usability of a brief enhanced anxiety sensitivity treatment to reduce anxiety sensitivity and functional impairment in Veterans.

Detailed Description

This study tests a treatment with two components: first, there is a single session face-to-face virtual intervention delivered by the counselor or therapist via VA Video Connect software. Second, a mobile app (mPRO) is used for EMA and to deliver EMI components. Veterans will be enrolled following informed consent. The research staff will read the measures to the Veteran who will verbally provide their answers. Veterans will next complete the baseline assessment. At the baseline assessment, Veterans meet with the Project Coordinator by phone or virtually to complete a consenting process, guidance on the video software being used, and set-up and guidance on use of the mobile app. Following the baseline assessment, participants will be scheduled to receive the face-to-face virtual intervention followed by two weeks of EMA/EMI via mPRO. At the end of the two weeks, Veterans will complete a post-intervention assessment appointment. The post-intervention assessment includes an exit interview for participants to provide additional feedback regarding acceptability of the intervention. Follow-up assessment appointments will be completed at the 1-month and 3-month follow-ups.

Registry
clinicaltrials.gov
Start Date
September 1, 2022
End Date
August 30, 2024
Last Updated
10 months ago
Study Type
Interventional
Study Design
Single Group
Sex
All

Investigators

Responsible Party
Sponsor

Eligibility Criteria

Inclusion Criteria

  • Are English-speaking
  • Score equal to or greater than 9 on the SSASI indicating elevated anxiety sensitivity
  • Score equal to or greater than 5 on the WHODAS 2.0

Exclusion Criteria

  • Veterans with cognitive impairment as measured scoring equal to or greater than 11 on the Blessed
  • Orientation-Memory-Concentration Test
  • Veterans without access to a smartphone
  • Veterans with significant medical or psychiatric conditions that may limit participation, including:
  • severe documented schizophrenia
  • an ongoing active psychotic or manic state
  • an imminent suicide crisis will be excluded from our study and provided the appropriate referral

Outcomes

Primary Outcomes

Mean Change in Anxiety Sensitivity

Time Frame: From baseline to post-intervention (two-weeks after virtual treatment session)

Anxiety sensitivity will be measured via the Anxiety Sensitivity Index-3, an 18-item self-report measure assessing fear of negative consequences of anxiety-related symptoms. Scores range from 0 to 72 with higher scores indicating worse anxiety sensitivity.

Program Satisfaction

Time Frame: Post-intervention (two weeks after virtual treatment session)

Program satisfaction will be measured using an adapted 11-item version of the Program Satisfaction Questionnaire that assesses both general program satisfaction (usefulness, acceptability) and perceived utility of program components (psychoeducation, EMA/EMI schedule). Average scores range from 1 to 5 with higher scores indicating greater satisfaction.

Mean Change in Functional Impairment

Time Frame: From baseline to post-intervention (two-weeks after virtual treatment session)

Functional impairment will be measured using the 12-item version of the World Health Organization Disability Assessment 2.0. This scale assesses functional impairment across six domains: 1) understanding and communication, 2) self-care, 3) mobility, 4) interpersonal relationships, 5) work and household roles, and 6) community and civic roles. Scores range from 0 to 48 with higher scores indicating worse functional impairment.

Secondary Outcomes

  • Mean Changes in Anxiety(From baseline to follow-up (measured six weeks after intervention session))
  • Mean Changes in Worry Related to the COVID-19 Pandemic(From baseline to follow-up (measured six weeks after intervention session))
  • Mean Changes in Avoidance Due to the COVID-19 Pandemic(From baseline to follow-up (measured six weeks after intervention session))
  • Mean Changes in Functional Impairment Due to the COVID-19 Pandemic(From baseline to follow-up (measured six weeks after intervention session))
  • Mean Change in Depression(From baseline to follow-up (measured six weeks after intervention session))

Study Sites (1)

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