Advancing Tools for Human Early Lifecourse Exposome Research and Translation- Adolescence Follow-up of the HELIX Subcohort

Not Applicable

Completed

• Conditions: Exposure; Health Behavior; Environment
• Interventions: Other: HELIX's follow-up

• Registration Number: NCT05158010
• Lead Sponsor: Poitiers University Hospital

Brief Summary

ATHLETE will set up a prospective Europe-wide exposome cohort covering the first 2 decades of the life course, which will integrate data on the external, chemical, physical,behavioral, and social domains of the exposome, as well as on health outcomes and biological omics responses, from preconception until adolescence. As part of ATHLETE, the investigators will follow up a unique existing exposome cohort into adolescence (the HELIX Subcohort).

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2021-03-19
• Study Start: 2021-11-10
• Study First Submitted QC: 2021-12-09
• Study First Posted: 2021-12-15
• Status Verified: 2022-06
• Primary Completion: 2022-06-25
• Study Completion: 2022-06-25
• Last Update Submitted: 2022-06-30
• Last Update Posted: 2022-07-01

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

For the adolescent :

• Subject of the EDEN cohort included in the Helix cohort in 2014-2015 in Poitiers (16-19 years old)
• Subject benefiting from a Social Security scheme or benefiting through a third party

For the person legally responsible :

• The legal guardian, if possible the mother, of the adolescent included in Athlete ;
• Subject benefiting from a Social Security scheme or benefiting through a third person;
• Free subject, without tutorship or guardianship or subordination.

Exclusion Criteria

• Concomitant participation in another clinical research study.
• Persons not benefiting from a Social Security scheme or not benefiting through a third party.
• Adolescents who are incapable or who do not give their consent to follow the study procedures

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
HELIX's follow-up	HELIX's follow-up	-

Primary Outcome Measures

Name	Time	Method
Urinary biomarkers exposure	One week	Measure of phtalates, phenols, pesticides, (organophosphorus pesticides, metabolites of pyrethroids, 2,4-dichlorophenoxyacid, boscalid, imazalil), cotinine, glycol ethers, polycyclic aromatic hydrocarbon, creatinine, exogenous metabolomics, in a weekly pool of urine collection

Trial Locations

Locations (1)

C.H.U. de Poitiers; 🇫🇷 Poitiers, France