Dose escalation study for inoperable esophageal cancer patients.
- Conditions
- inoperable oesophageal tumorsdefinitive chemoradiationdose escalation
- Registration Number
- NL-OMON25587
- Lead Sponsor
- dept of Radiotherapy, AMC, AmsterdamArhems Radiotherapeutisch Institute, Arnhemdept of oncology, Erasmusmc, Rotterdam
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 260
Inclusion Criteria
1. T1-4, N0-3,M0 medically or technically inoperable esophageal or junction tumors;
2. Histology proven;
Exclusion Criteria
1. Esophageal fistula;
2. Both pathological nodes at supraclavicular and truncus coeliacus level;
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method ocal tumor control in the esophagus. Measured by anamnesis at 1, 2, 5, 8, 12, 18, 24, 36, 48 and 60 months, and by CT scans at 2, 8 and 18 months. Endoscopy and PET CT scan will be performed on indication.
- Secondary Outcome Measures
Name Time Method Survival and grade 3-4 toxicity, measured at the same interval as local tumor control using an oesofagus toxicity form.