DRKS00000100
Not yet recruiting
未知
The influence of multimodal physical activity on cognition and everyday life competence in patients with early Alzheimer's disease - Sport & KOG
niversitätsklinikum EssenUniversität Duisburg-Essen0 sites300 target enrollmentMarch 24, 2009
Overview
- Phase
- 未知
- Intervention
- Not specified
- Conditions
- G30
- Sponsor
- niversitätsklinikum EssenUniversität Duisburg-Essen
- Enrollment
- 300
- Status
- Not yet recruiting
- Last Updated
- last year
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •diagnosis of Alzheimer's dementia according to NINCDS\-ADRDA respectively ICD 10
- •\-Mini\-Mental\-State\-Test (20 \- 25\) at screening
- •\-Hachinski Ischemia Scale \<\=4 at screening
- •\-CT or MRT, maximal 2 years old, compatible with Alzheimer's dementia
- •\-Geriatric Depression Scale (GDS) \<\=4 (15\-item scale)
- •\-ambulant patients
- •\-exercise ECG analysed by specialist in internal medicine
- •\-caregiver (contact 3 times a week, overall 5 hours a week), who can report the patient's state of health
- •\-informed consent form signed by patient and caregiver
Exclusion Criteria
- •\-diagnosis of a possible, probable or certain vascular dementia NINDS\-AIREN criteria
- •\-missing approval ability, missing ability to take part in intervention programme or missing compliance
- •\-intake of following drugs with change of dosage during the last 3 months before baseline: antidepressants, tranquilizer / sleeping pills, anti\-psychotica or anti\-epileptica
- •\-excessive alcohol, drug or medicament abuse. Diagnosis of drug abuse or drug addiction (ICD\-10\) as a primary clinical diagnosis, which indicates the initiation or continuation of a medical treatment of this disorder
- •\-clinically relevant neurologic or psychiatric diseases, such as severe depression, schizophrenia, epilepsy or Parkinson's disease
- •\-participation in a pharmaceutical trail 2 months before baseline
- •\-decompensated or poorly regulated diabetes
- •\-decompensated or poorly regulated hypertonia
- •\-cardiovascular event during the last 3 months e.g. cardiac catheterization, vascular surgery, acute coronary syndrome, myocardial infarction or unstable angina, clinical relevant cardiac dysrhythmia, cardiac surgery, angiography with stent implantation
- •\-other clinically significant aberrances in clinical, neurologic, laboratory medicine examination, clinically relevant ECG changes, which could impair the patient's health related to the trail
Outcomes
Primary Outcomes
Not specified
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