Contrast Enhanced Susceptibility Weighted Imaging (SWI) for Characterization of Carotid Plaque
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 25
- 试验地点
- 2
- 主要终点
- Detection rate of findings of vulnerable carotid plaque
研究概览
简要总结
This study aims to compare image-based characteristics of carotid walls between symptomatic side and the opposite side. The design of this study is phase IV, prospective observational study.
详细描述
Atherosclerosis of craniocervical arteries are one of most important causes of stroke. Carotid artery is the most frequent site of atherosclerosis. Recent research in carotid artery covers not only morphology of lumen but also direct visualization of carotid plaque or vessel wall. Vulnerable carotid plaques share pathologic features of intra-plaque inflammation and hemorrhage. There have been reports about post-contrast SWI in the field of vascular imaging. We hypothesized SWI is so sensitive to gadolinium based contrast agent and hemorrhage that contrast-enhanced SWI can visualize vulnerable carotid plaque. The purpose of this study is to investigate gadolinium-enhanced SWI in detection of vulnerable carotid plaque and compare it with MP-RAGE and DANTE T1-SPACE. This can be used to guide proper treatment for stroke.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 20 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with acute or recent (within 3months) stroke or TIA
- •50-99% stenosis of internal carotid artery by NASCET criteria
- •Written informed consent, prior to registration
排除标准
- •Hemorrhagic stroke
- •Previous history of carotid endarterectomy (CEA), angioplasty, or stenting
- •Contraindication for MR imaging
- •Hypersensitivity to gadolinium based contrast media
- •Pregnant or lactating women
- •Patients under age of 19-year-old
- •Renal condition : eGFR < 60
- •Patients unable and/or unwilling to comply with treatment or study instructions.
结局指标
主要结局
Detection rate of findings of vulnerable carotid plaque
时间窗: within 3 days after enrollment
次要结局
- Accuracy in delinating geometry of carotid inner lumen and outer wall(within 3 days after enrollment)
研究者
Hyun Seok Choi, M.D.
Associate professor
Seoul St. Mary's Hospital