Caffeine Consumption and Mortality in Diabetes

Completed

• Conditions: Diabetes Mellitus

• Registration Number: NCT03367806
• Lead Sponsor: João Sérgio Neves

Brief Summary

Previous studies suggested an inverse relationship between coffee consumption and mortality in the general population. Furthermore, an inverse association between coffee consumption and serum biomarkers of inflammation and insulin resistance has been described. Prospective studies showed that coffee consumption might be associated with reduction in the incidence of type 2 diabetes. Although caffeine consumption appears to be associated with a decreased risk of developing type 2 diabetes, the relationship between caffeine consumption and mortality in patients with diabetes remains uncertain. The current analysis aimed to assess the effects of caffeine consumption and caffeine source on all-cause, cardiovascular and cancer mortality among patients with diabetes.

Detailed Description

Not available

Study Timeline

• Study Start: 1999-01
• Primary Completion: 2011-12
• Study Completion: 2011-12
• Status Verified: 2017-12
• Study First Submitted: 2017-12-05
• Study First Submitted QC: 2017-12-05
• Last Update Submitted: 2017-12-05
• Study First Posted: 2017-12-11
• Last Update Posted: 2017-12-11

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 3052

Inclusion Criteria

• NHANES participants from 1999 to 2010 above 18-year old, with diagnosis of diabetes

Exclusion Criteria

• Implausible alimentary reports (defined as consumption of less than 500 kcal/day or more than 3500 kcal/day)
• Missing information on caffeine consumption
• Missing information on mortality

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
All-cause mortality	From baseline until death or censoring on 31 December 2011, whichever came first, assessed up to 12 years	All-cause mortality as assessed by NHANES linked National Death Index public-access

Secondary Outcome Measures

Name	Time	Method
Cardiovascular mortality	From baseline until death or censoring on 31 December 2011, whichever came first, assessed up to 12 years	Cardiovascular mortality as assessed by NHANES linked National Death Index public-access
Cancer mortality	From baseline until death or censoring on 31 December 2011, whichever came first, assessed up to 12 years	Cancer mortality as assessed by NHANES linked National Death Index public-access