Impact of Chemotherapy on Ovarian Reserve in Young Women With Breast Cancer
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Ovarian Reserve
- Sponsor
- Nantes University Hospital
- Enrollment
- 250
- Locations
- 11
- Primary Endpoint
- To evaluate the effects of adjuvant or neoadjuvant chemotherapy treatment on ovarian reserve for in situ breast cancer patients
- Status
- Terminated
- Last Updated
- 9 years ago
Overview
Brief Summary
The aim of this protocol is to study the deleterious impact of adjuvant chemotherapy or neoadjuvant chemotherapy on ovarian reserve in young women suffering from breast cancer. A new relevant ovarian reserve marker, serum Anti-Mullerian Hormone, will be used in order to evaluate precisely the impact of chemotherapy on ovaries during chemotherapy administrations and after during follow-up (24 months). This strategy offers 2 main advantages : no modification of the traditional care of patients (treatment, organisation, follow up ...) and use of a non invasive marker (serum). The final objective is to give precise information to patients on their future fertility after remission.
Investigators
Eligibility Criteria
Inclusion Criteria
- •female 18-39 years
- •suffering from breast cancer
- •treated with adjuvant or neoadjuvant chemotherapy
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
To evaluate the effects of adjuvant or neoadjuvant chemotherapy treatment on ovarian reserve for in situ breast cancer patients
Time Frame: 24 months
Serum anti-Müllerian hormone concentration will be measured at each chemotherapy administration and 24 months follow-up after chemotherapy completion