Imaging of Ventricular Reversed Remodeling After Double Lung Transplantation in Patients With Pulmonary Arterial Hypertension
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Pulmonary Arterial Hypertension
- Sponsor
- University Medical Center Groningen
- Enrollment
- 17
- Locations
- 1
- Primary Endpoint
- Ventricular remodeling on cardiac magnetic resonance
- Status
- Completed
- Last Updated
- 6 years ago
Overview
Brief Summary
The investigators will evaluate ventricular reversed remodelling after double lung transplantation (LTX) in patients with pulmonary arterial hypertension (PAH), measured with cardiac magnetic resonance imaging (MRI). Reversed remodelling will be compared with control patients without PAH (e.g. Cystic Fibrosis) who will also undergo LTX.
Detailed Description
In this study, pre-LTX and six-months post-LTX measurements will be compared with each other and between the primary and control group. Pre- and post-LTX measurements include: Past medical history: Including basic diagnosis; interventions, surgery and transplant related complications (re-operations, hospitalizations, infections) and medication history; These data will be collected by studying the medical files including surgical reports. Present medical history: Including NYHA class. Physical examination: Including length and weight. Cardiac Magnetic Resonance Imaging: * Ventricular volume, function and mass measurements * Flow measurements of the pulmonary artery and aorta * Disease specific measurements (e.g. septal bowing, RV trabecularisation, etc.) * T1-mapping Transthoracic Echocardiography Resting ECG: Disease specific electrophysiological findings (e.g. QRS-duration, right bundle branch block). Laboratory evaluation: * NT-pro-BNP * eGFR * Remaining serum will be stored.
Investigators
J.P. van Melle
MD PhD
University Medical Center Groningen
Eligibility Criteria
Inclusion Criteria
- Not provided
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
Ventricular remodeling on cardiac magnetic resonance
Time Frame: Six months postoperative
Decrease in LV end-systolic eccentricity index
Secondary Outcomes
- Change in heart failure biomarkers(Six months postoperative)
- Functional remodeling patterns after LTX, assessed with echocardiography(Six months postoperative)
- Electrocardiographic remodeling(Six months postoeprative)