Imaging of Ventricular Reversed Remodeling After Double Lung Transplantation in Patients With Pulmonary Arterial Hypertension
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 17
- 试验地点
- 1
- 主要终点
- Ventricular remodeling on cardiac magnetic resonance
研究概览
简要总结
The investigators will evaluate ventricular reversed remodelling after double lung transplantation (LTX) in patients with pulmonary arterial hypertension (PAH), measured with cardiac magnetic resonance imaging (MRI). Reversed remodelling will be compared with control patients without PAH (e.g. Cystic Fibrosis) who will also undergo LTX.
详细描述
In this study, pre-LTX and six-months post-LTX measurements will be compared with each other and between the primary and control group.
Pre- and post-LTX measurements include:
Past medical history: Including basic diagnosis; interventions, surgery and transplant related complications (re-operations, hospitalizations, infections) and medication history; These data will be collected by studying the medical files including surgical reports.
Present medical history: Including NYHA class.
Physical examination: Including length and weight.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- 未提供
排除标准
- 未提供
结局指标
主要结局
Ventricular remodeling on cardiac magnetic resonance
时间窗: Six months postoperative
Decrease in LV end-systolic eccentricity index
次要结局
- Change in heart failure biomarkers(Six months postoperative)
- Functional remodeling patterns after LTX, assessed with echocardiography(Six months postoperative)
- Electrocardiographic remodeling(Six months postoeprative)
研究者
J.P. van Melle
MD PhD
University Medical Center Groningen