The effect of MitoQ supplementation on skeletal muscle exercise responses in older individuals

Not Applicable

Recruiting

Conditions: Oxidative stress
Musculoskeletal - Normal musculoskeletal and cartilage development and function
Physical Medicine / Rehabilitation - Other physical medicine / rehabilitation

Registration Number: ACTRN12623000687695

Lead Sponsor: Australian Catholic University

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: All

Target Recruitment: 24

Inclusion Criteria

Aged 65-80 years, sedentary (complete less than 150 mins of moderate intensity exercise per week and have not performed regular physical activity during the previous 6 months), healthy BMI between 18 and 30 kg/m^2, pass the Exercise and Sports Science Australia (ESSA) pre-exercise screening tool and obtain GP clearance to perform high-intensity exercise.

Exclusion Criteria

Acute illness, musculoskeletal, cardiovascular, or neurological disorder that could place the participant at risk of injury or illness resulting from the exercise; coronary heart disease, congestive heart failure, uncontrolled hypertension, diabetes mellitus, bleeding disorder, taking drugs that increase the risk of bleeding or other medications that may impact exercise responses, taking antioxidant supplements in the 6 weeks prior to recruitment, smoking.

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The effect of MitoQ supplementation on mitochondrial reactive oxygen species (ROS) levels measured in skeletal muscle biopsies using fluorimetry[ Baseline (pre-supplementation) and immediately after completion of the 12-week supplementation period (pre-exercise)]

Secondary Outcome Measures