The effects of oxygen supplementation on oxidative stress biomarkers in the Emergency Department.

Withdrawn

• Conditions: Patienten met aandoeningen waarvoor zuurstof therapue noodzakelijk is voor of bij binnenkomst op de SEH; Oxidative stress; toxic effects of oxygen

• Registration Number: NL-OMON46013
• Lead Sponsor: Medisch Centrum Leeuwarden

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 15 April 2024

Recruitment & Eligibility

• Status: Withdrawn
• Sex: Not specified
• Target Recruitment: 100

Inclusion Criteria

- Non-trauma patients presenting to the ED who already receive oxygen therapy started by EMS or in whom oxygen therapy is started in the ED.
- Adult (i.e. age > 18 years)
- Able to provide (deferred) informed consent themselves or informed consent can be obtained via next of kin or legal guardian

Exclusion Criteria

- Hypoxia (sat <94% or PaO2 < 10 kPa) despite oxygen suppletion
- Patients who receive oxygen therapy started by EMS > 30 minutes
- Patients with an acute coronary syndrome (ACS)
- Patients with Chronic Obstructive Pulmonary Syndrome (COPD) Gold III or IV
- Patient who were in cardiac arrest pre-hospital or who go into cardiac arrest in the first hour after arrival to the ED

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The occurrence of oxidative stress biomarkers in patients who receive oxygen<br /><br>therapy in the ED. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>The association between blood oxygen saturation and the occurrence of the<br /><br>different oxidative stress biomarkers.</p><br>