The effect of oxygen supplementation on oxidative stress in the Emergency Department.

Withdrawn

• Conditions: patienten met aandoeningen waarvoor zuurstof therapie noodzakelijk is voor of bij binnenkomst op de SEH; Oxidative stress; toxic effects of oxygen

• Registration Number: NL-OMON49342
• Lead Sponsor: niversitair Medisch Centrum Groningen

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 15 April 2024

Recruitment & Eligibility

• Status: Withdrawn
• Sex: Not specified
• Target Recruitment: 100

Inclusion Criteria

- Non-trauma patients presenting to the ED who already receive oxygen therapy
started by EMS or in whom oxygen therapy is started in the ED an in whom an
infection is suspected
- Adult (i.e. age > 18 years)
- Able to provide (deferred) informed consent themselves or informed consent
can be obtained via next of kin or legal gardian

Exclusion Criteria

- SpO2 < 94% or PaO2 < 9.5 kPa despite oxygen therapy
- Chronic Obstructive Pulmonary Syndrome (COPD) Gold III or IV

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The variation in FiO2, PaO2, SpO2 and levels of oxidative stress among patients<br /><br>with an infection admitted to the ED who receive oxygen therapy.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>- The correlation between baseline PaO2 and levels of oxidative stress in blood<br /><br>and urine in non-trauma<br /><br>ED patients receiving oxygen therapy;<br /><br>- To investigate if dynamic changes in PaO2 over time are related to changes in<br /><br>biomarkers of oxidative stress. </p><br>