Optimising functional capacity in patients with ventricular dysfunction: A focus on enhancing skeletal muscle mechanics
Not Applicable
- Conditions
- Chronic Heart FailureCardiovascular - Coronary heart disease
- Registration Number
- ACTRN12612000242820
- Lead Sponsor
- The University of Western Australia
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot yet recruiting
- Sex
- All
- Target Recruitment
- 60
Inclusion Criteria
Chronic Heart Failure
New York Heart Association (NYHA) class II-IV
ejection fraction <50%
Exclusion Criteria
Unstable angina or exercise-induced Ischaemia at low exercise levels
Severe aortic stenosis
Severe mitral or aortic regurgitation
Hypertrophic cardiomyopathy
treated hypertension >160/100mmHg at rest)
Hypercholesterolaemia (total cholesterol >7.0 mmolL-1)
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Exercise Capacity (Peak rate of oxygen consumption; VO2)<br><br>We will assess peak VO2 using a modified chronotropic assessment protocol in which stages are incremented by set and regular workloads. Heart rate and rhythm and<br>oxygen saturation will be measured continuously by 12-lead Electrocardiogram (ECG) and pulse oximeter respectively.<br>Blood pressure, rating of perceived exertion (Borg Scale) and perceived dyspnoea (Borg Scale) will<br>be recorded during the final 30 seconds of each level. Indirect calorimetry will be measured employing a Vmax metabolic cart to establish VO2peak.[at baseline and at 6 and 12 weeks after intervention commencement]
- Secondary Outcome Measures
Name Time Method Muscle Mechanical Work Capacity. This outcome measure will be measured on an isokinetic dynamometer (Biodex), whereby the participant will push as hard as possible (e.g. one repetition maximum) against an instrumented footplate throughout the ankle range of motion. Recordings from the footplate will measure the torque and displacement of the ankle and will be used to calculate total mechanical work. These measurements will be repeated 3-4 times with a minimum of two minutes rest between contractions.[at baseline and at 6 and 12 weeks after intervention commencement]