Ability of Bedside Ultrasound to Predict and Optimize Metabolic and Neurodevelopmental Outcomes in Premature Infants in the Neonatal Intensive Care Unit
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Premature Birth
- Sponsor
- University of Minnesota
- Enrollment
- 37
- Locations
- 1
- Primary Endpoint
- Blood pressure at 4 mo
- Status
- Completed
- Last Updated
- last year
Overview
Brief Summary
The objective of the project is to identify clinical factors (nutritional and non-nutritional) which are associated with ultrasound measurements of muscle and adipose tissue and to determine whether these ultrasound measurements are predictive of later metabolic and neurodevelopmental outcomes in premature infants, a population at risk for developmental delay, obesity, and metabolic disease. The investigators expect that a better understanding of these relationships will lead to the incorporation of ultrasound into routine nutritional management of preterm infants and allow for future optimization of their overall health and development.
Detailed Description
The specific aims are as follows: 1. To identify clinical factors that are associated with muscle and adipose tissue measurements. The investigators will examine the relationship between clinical factors such as calorie and protein intake during hospitalization, days on parenteral nutrition, C-Reactive Protein and other clinical surrogates for inflammation and both muscle and adipose tissue measured bi-weekly using bedside ultrasound. The investigators will collect anthropometric and ultrasound measurements bi-weekly and whole body composition (utilizing ADP) data at 35 weeks postmenstrual age (PMA)/discharge from the Neonatal Intensive Care Unit. All other clinical data will be collected throughout the hospital stay. 2. To determine whether muscle thickness and cross-sectional area are predictive of improved neurodevelopmental outcomes. The investigators will assess the relationship between ultrasound measurements of muscle with neurodevelopmental outcomes at 35 weeks PMA/discharge and 4 months corrected age. The investigators will utilize Event Related Potentials (ERP) to measure speed of processing and recognition memory as early markers of brain development. 3. To determine whether measurements of adipose tissue are predictive of later adverse metabolic outcomes. The investigators will assess the relationship between adipose tissue thickness and blood pressure and total body adiposity (using air-displacement plethysmography) at 35 weeks PMA/discharge and 4 months corrected age.
Investigators
Eligibility Criteria
Inclusion Criteria
- •preterm infants born between 25 and 34+6 weeks gestation admitted to University of Minnesota Masonic Children's Hospital Neonatal Intensive Care Unit
- •medically stable at time of air displacement measurements
Exclusion Criteria
- •infants that require medical support preventing ADP measurements from being taken
Outcomes
Primary Outcomes
Blood pressure at 4 mo
Time Frame: 4 months corrected age
blood pressure (systolic and diastolic)
Percent body fat inpatient
Time Frame: 4 months corrected age
percent body fat (kg/kg)
Fat-free mass outpatient
Time Frame: 4 months corrected age
fat-free mass (kg)
Percent body fat outpatient
Time Frame: 4 months corrected age
percent body fat (kg/kg)
Ultrasound adipose measures outpatient
Time Frame: 4 months corrected age
adipose tissue (cm)
Ultrasound adipose measures inpatient
Time Frame: 35 weeks corrected age
adipose tissue (cm)
Ultrasound muscle measures inpatient
Time Frame: 35 weeks corrected age
muscle thickness (cm)
Length data outpatient
Time Frame: 4 months corrected age
length in cm
Fat mass inpatient
Time Frame: 35 weeks corrected age
fat mass (kg)
ERP data inpatient
Time Frame: 35 weeks corrected age
ERP paradigm
Weight data inpatient
Time Frame: 35 weeks corrected age
weight in kg
Length data inpatient
Time Frame: 35 weeks corrected age
length in cm
Weight data outpatient
Time Frame: 4 months corrected age
weight in kg
ERP data outpatient
Time Frame: 4 months corrected age
ERP paradigms
Blood pressure at 35 weeks
Time Frame: 35 weeks corrected age
blood pressure (systolic and diastolic)
Fat-free mass inpatient
Time Frame: 35 weeks corrected age
fat-free mass (kg)
Fat mass outpatient
Time Frame: 4 months corrected age
fat mass (kg)
Ultrasound muscle measures outpatient
Time Frame: 4 months corrected age
muscle measurements (cm)