Use of Bedside Ultrasound to Monitor Body Composition and Neurodevelopmental Outcomes in Formerly-Premature Toddlers
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Prematurity
- Sponsor
- University of Minnesota
- Enrollment
- 80
- Locations
- 1
- Primary Endpoint
- Ultrasound Measurements
- Status
- Completed
- Last Updated
- last year
Overview
Brief Summary
The overall objective of the proposal is to evaluate the ability of ultrasound to predict the body composition of toddlers in the outpatient clinical setting and to evaluate the relationship between body composition and neurodevelopment.
Detailed Description
The investigators will address the hypothesis in the following Specific Aims: Specific Aim 1: Validate ultrasound as a method to measure whole body fat mass and fat-free mass in toddlers. Body composition will be assessed using ultrasound measurements and the validated method of air displacement plethysmography (ADP). Specific Aim 2: Determine the effect of a handheld Force-Measuring Ultrasound Probe on intra- and inter-observer variability in ultrasound measurements. A device which measures the force applied to the ultrasound probe will be used to obtain measurements of muscle and adipose tissue thickness (biceps, abdomen, and quadriceps) in toddlers.
Investigators
Eligibility Criteria
Inclusion Criteria
- •toddlers who were ≤ 36 weeks gestational age (GA) at birth who attend the University of Minnesota Masonic Children's Hospital NICU Follow Up Clinic
- •written consent obtained from a parent before or at time of visit
Exclusion Criteria
- •toddlers who require medical support that prevents them from having ADP measurements taken
- •those with an inability to sit in a supported seat for 5 minutes
- •those weighing less than 10 kg
Outcomes
Primary Outcomes
Ultrasound Measurements
Time Frame: through study completion, up to 2 years
Tissue thickness (adipose and muscle) will be measured in cm using the ultrasound probe.
Secondary Outcomes
- Body Composition Measurements(through study completion, up to 2 years)
- Neurodevelopmental Status for 3 and 4 year olds(through study completion, up to 2 years)
- Neurodevelopmental Status for 2 year olds(through study completion, up to 2 years)