eoadjuvant chemoradiotherapy with protons for resectable esophageal cancer

Not Applicable

• Conditions: Neoplasms

• Registration Number: KCT0005576
• Lead Sponsor: ational Cancer Center

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 2 December 2020

Recruitment & Eligibility

• Status: ot yet recruiting
• Sex: All
• Target Recruitment: 68

Inclusion Criteria

ECOG 0~2
- Good Organ Function
(1) Absolute neutrophil count > 1500/mm3, platelets =100,000/mm3, Hemoglobin = 9g/dl
(2) CCr = 20mL/min (Cockroft-Gautl))
(3) Total billrubin =1.5X UNL, AST /ALT =2.5X UNL
- FEV1> 1.5L
- Singed Informed Consesnt

Exclusion Criteria

1. Have a history of esophageal Cancer who previously received topical therapy such as esophageal submucosal resection, surgery, radiation therapy or chemotherapy.
2. Have a distant metastasis lesion
3. Have a history of severe hypersenstivity to mannitol, paclitacxel, neoplatin or platinum based durg.
4. Have a hearing damage.
5. Have a hemorrhagic tumor
6. Have a additional malignancy is not disease free for more than 3 years. (except cured basal or smuamous skin cancer, cervial carcinoma in situ)
7. pregnant or breastfeeding
8. uncontrolled pychiatric disease, severy head injury, chronic alcoholism or drug addiction. CNS disease.
9 Have a weight loss of more than 10% during recent 6 months

Study & Design

• Study Type: Interventional Study
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Overall Best Response rate

Secondary Outcome Measures

Name	Time	Method
Safety evaluation