Metabolic Consequences of Moderate Weight Gain - Role of Dietary Fat Composition (LIPOGAIN)

Not Applicable

Completed

• Conditions: Healthy
• Interventions: Other: Saturated fatty acid group; Other: Polyunsaturated fatty acid group

• Registration Number: NCT01427140
• Lead Sponsor: Uppsala University

Brief Summary

The purpose of this study is to investigate the metabolic consequences of a moderate weight gain and if the type of dietary fat (saturated versus polyunsaturated) can modify the effects in young healthy adults. Hypothesis: the type of dietary fat can modify the effects of weight gain.

Detailed Description

Specific goals:

* Investigate if dietary fat composition influences liver fat accumulation and metabolic risk factors in response to moderate weight gain

* Investigate if polyunsaturated fat (PUFA) in the diet could counteract any unfavorable metabolic changes that are expected to accompany moderate weight gain

* Investigate effects of weight gain and dietary fat composition on markers of vascular health

Study Timeline

• Study First Submitted: 2011-08-19
• Study First Submitted QC: 2011-08-31
• Study Start: 2011-09
• Study First Posted: 2011-09-01
• Status Verified: 2011-12
• Primary Completion: 2011-12
• Study Completion: 2011-12
• Last Update Submitted: 2011-12-08
• Last Update Posted: 2011-12-09

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 41

Inclusion Criteria

• Healthy,
• Body Mass Index 18-27

Exclusion Criteria

• Liver disease,
• Coronary heart disease,
• Diabetes mellitus,
• Malignant diseases,
• Alcohol or drug abuse,
• Magnetic Resonance-incompatibility,
• Abnormal clinical chemistry,
• Use of drugs that significantly effects energy metabolism,
• Heavy exercise,
• Pregnancy or lactation,
• Allergy of gluten, egg or milk protein

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Saturated fatty acid group	Saturated fatty acid group	Addition of saturated fatty acids to the diet inte the form of pastries
Polyunsaturated fatty acid group	Polyunsaturated fatty acid group	Addition of polyunsaturated fatty acids to the diet in the form of pastries

Primary Outcome Measures

Name	Time	Method
Hepatic steatosis by magnetic resonance tomography (MRT)	6 weeks

Secondary Outcome Measures

Name	Time	Method
Triglycerides	6 weeks
Cholesterol	6 weeks
Apolipoprotein B (ApoB)	6 weeks
Apolipoprotein A1 (ApoA1)	6 weeks
Glucose	6 weeks
high density lipoprotein (HDL)	6 weeks
low density lipoprotein (LDL)	6 weeks
Insulin	6 weeks
Aspartate aminotransferase (ASAT)	6 weeks
Alanine aminotransferase (ALAT)	6 weeks
Gamma glutamyl transpeptidase (GGT)	6 weeks
Homeostasis model of assessment insulin resistance (HOMA-IR)	6 weeks
C-reactive protein (CRP)	6 weeks
Proinsulin	6 weeks
Endostatin	6 weeks
Pentraxin-3 (PTX-3)	6 weeks
Endothelin-1 (ET-1)	6 weeks
E-selectin	6 weeks
Cathepsin-S	6 weeks
Cystatin C	6 weeks

Trial Locations

Locations (1)

Uppsala University Hospital, Uppsala Science Park; 🇸🇪 Uppsala, Sweden