Satiety, Meal Frequency and Nutritional Aspects

Not Applicable

Terminated

• Conditions: Volunteers

• Registration Number: NCT01573988
• Lead Sponsor: Hospices Civils de Lyon

Brief Summary

In this study, the investigators are interested in assessing the effects of the isocaloric increase of eating frequency on appetite and metabolism. How the consumption of an isocaloric breakfast in four intakes vs. one can modify satiety and appetite control in lean and obese subjects through :

* the physiological consequences : difference in postprandial kinetics of glucose, non esterified fatty acid, triglyceride, the secretion of satiety gut hormone (insulin, ghrelin, leptin and cholescystokinine (CCK), peptide YY (PYY), glucagon-like peptide-1 (GLP-1), nutrients oxidative fate and plasmatic oxidative stress (Malondialdehyde (MDA), glutathion, lipid hydroperoxides)

* eating behavior during an ad libitum buffet test meal

Detailed Description

Not available

Study Timeline

• Study Start: 2010-08
• Primary Completion: 2012-04
• Study Completion: 2012-04
• Study First Submitted: 2012-04-04
• Study First Submitted QC: 2012-04-06
• Study First Posted: 2012-04-10
• Status Verified: 2012-09
• Last Update Submitted: 2012-09-26
• Last Update Posted: 2012-09-27

Recruitment & Eligibility

• Status: TERMINATED
• Sex: Male
• Target Recruitment: 37

Inclusion Criteria

• No smokers
• BMI 20 to 35 kg/m2
• Moderate physical activity
• Safety during medical consultation
• Feeding behavioural phenotype (Dutch Eating Questionnaire, Three Eating Factor Questionnaire)

Exclusion Criteria

• Medical history which may affect glucose metabolism (diabetes, renal or hepatic failure, thyroid dysfunction, Cushing syndrome, acromegaly...)
• Medical history which affect nutrient absorption (gastro-intestinal and pancreatic disease, gastrectomy, colectomy...)
• Drug use in the last two months that could affect glucose metabolism (steroids, topical gastric preparation, anorectic drugs...)
• Eating disorders
• Claustrophobic subjects

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Ghrelin plasmatic concentration	240 minutes after breakfast beginning (just before the lunch)

Secondary Outcome Measures

Name	Time	Method
Satiety through food intakes (quantitative) at the ad libitum buffet test meal	Since the beginning of the buffet test meal (240 minutes after breakfast beginning) to the end of the meal (at the latest 270 minutes after breakfast beginning).
Satiety through visual analogue scale	240 minutes after breakfast beginning (just before the lunch)
Plasma metabolite concentrations (glycaemia, non esterified fatty acid,	kinetics during 430 minutes
Endocrine concentrations (insulin, ghrelin, GLP-1, PYY, leptin, C-peptide)	kinetics during 430 minutes
Plasma markers of oxidative stress (MDA, gluthation, lipid hydroxide)	kinetics during 430 minutes
Lipid oxidation	kinetics during 430 minutes
Eating behaviour at the buffet test meal by video recording (food choice, nutritional composition of the meal , kinetics of nutrient intake, meal structure, lunch duration)	during the buffet test meal (max : 30 minutes)

Trial Locations

Locations (1)

Centre Hospitalier Lyon Sud - Centre de Recherche en Nutrition Humaine; 🇫🇷 Pierre Bénite, France