Arginine and nitric oxide (NO) metabolism during bone healing and non-union development - early prognostic markers - Arginine and NO early prognostic markers for non-union development

Algemene Heelkunde0 个研究点目标入组 100 人开始时间: 待定最近更新: 2024年5月6日

适应症

试验速览

暂无简介。

•1. Written informed consent
•2. Age > 18 years
•3. Patient with a fracture of the femur or tibia at the primary surgical procedure and for which a surgical procedure providing bone debris is performed as therapy.

•1. Patients with another bone fracture in their recent medical history (results in
•disturbances in the arginine-NO metabolism)
•2. Infectious complications, such as infected pseudo-arthrosis (infections causes
•decreased argininine production, possibly resulting in impaired fracture healing).
•3. Use of chronic corticosteroids (suppresses the immunesystem) or nitrovasodilating
•medication (improves the NO metabolism).
•4. Patients with severe metabolic disturbances (liver, and renal insufficiency, diabetes).
•5. Patients with metastases, haematological malignancies or chemotherapy (results in
•disturbances in the arginine-NO metabolism).

发起方

Algemene Heelkunde